Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol.
infectious diseases
public health
respiratory infections
virology
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
02 Dec 2020
02 Dec 2020
Historique:
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
SARS-CoV-2 (COVID-19) has caused an international pandemic of respiratory illness, resulting in significant healthcare and economic turmoil. To date, no robust vaccine or treatment has been identified. Elemental zinc has previously been demonstrated to have beneficial effects on coronaviruses and other viral respiratory infections due to its effect on RNA polymerase. Additionally, zinc has well-demonstrated protective effects against hypoxic injury-a clear mechanism of end-organ injury in respiratory distress syndrome. We aimed to assess the effect of high-dose intravenous zinc (HDIVZn) on SARS-CoV-2 infection. The end of study analyses will evaluate the reduction of impact of oxygen saturations or requirement of oxygen supplementation. We designed a double-blind randomised controlled trial of daily HDIVZn (0.5 mg/kg) versus placebo. Primary outcome measures are lowest oxygen saturation (or greatest level of supplemental oxygenation) for non-ventilated patients and worst PaO Ethical approval was obtained through the independent Human Research Ethics Committee. Participant recruitment will commence in May 2020. Results will be published in peer-reviewed medical journals. ACTRN126200000454976.
Identifiants
pubmed: 33268419
pii: bmjopen-2020-040580
doi: 10.1136/bmjopen-2020-040580
pmc: PMC7712927
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Oxygen
S88TT14065
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e040580Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Clin Virol. 2020 Jun;127:104371
pubmed: 32315817
Crit Care. 2019 Sep 4;23(1):300
pubmed: 31484582
Metallomics. 2019 Aug 1;11(8):1330-1343
pubmed: 31204765
Lancet. 2012 Jun 2;379(9831):2072-8
pubmed: 22656335
Am J Clin Nutr. 2007 May;85(5):1293-300
pubmed: 17490965
Nature. 2020 Apr;580(7803):311-312
pubmed: 32273618
Crit Care. 2019 Feb 28;23(1):68
pubmed: 30819227
J Clin Transl Hepatol. 2020 Mar 28;8(1):18-24
pubmed: 32274342
J Oral Pathol Med. 2005 Aug;34(7):423-5
pubmed: 16011612
Nutrition. 2001 Oct;17(10):835-8
pubmed: 11684390
Crit Care. 2020 Apr 16;24(1):155
pubmed: 32299479
Lancet Respir Med. 2017 Jun;5(6):524-534
pubmed: 28664851
JPEN J Parenter Enteral Nutr. 2016 Aug;40(6):860-8
pubmed: 25700179
J Virol. 1999 Feb;73(2):1649-54
pubmed: 9882374
J Am Pharm Assoc (2003). 2004 Sep-Oct;44(5):594-603
pubmed: 15496046
J Clin Exp Hepatol. 2020 May-Jun;10(3):228-235
pubmed: 32405179
mSphere. 2020 Mar 18;5(2):
pubmed: 32188753
Am J Clin Nutr. 2005 Jul;82(1):103-10
pubmed: 16002807
J Med Virol. 2020 Jul;92(7):891-902
pubmed: 32314805
J Virol. 1974 Aug;14(2):282-91
pubmed: 4367904
Lancet. 2020 May 16;395(10236):1569-1578
pubmed: 32423584
PLoS Pathog. 2010 Nov 04;6(11):e1001176
pubmed: 21079686
Eur J Clin Nutr. 2011 Jan;65(1):125-31
pubmed: 20959856
J Trace Elem Med Biol. 2014 Oct;28(4):364-71
pubmed: 25200490
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
PLoS One. 2017 Jul 7;12(7):e0180028
pubmed: 28686686
Clin Respir J. 2018 Mar;12(3):857-864
pubmed: 28488366
Curr Cardiol Rep. 2020 Apr 21;22(5):32
pubmed: 32318865
Pharm Weekbl Sci. 1983 Oct 21;5(5):252-3
pubmed: 6646994
Lancet Respir Med. 2019 Apr;7(4):303-312
pubmed: 30898520
Int J Mol Sci. 2013 Mar 15;14(3):6044-66
pubmed: 23502468
Eur J Clin Nutr. 2016 Aug;70(8):886-93
pubmed: 27049031
J Nutr. 1991 Sep;121(9):1389-96
pubmed: 1880617
Pulm Circ. 2011 Apr-Jun;1(2):192-211
pubmed: 22034606
Antimicrob Agents Chemother. 2004 Mar;48(3):783-90
pubmed: 14982765
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 May;25(5):449-51
pubmed: 15957842
CMAJ. 2012 Jul 10;184(10):E551-61
pubmed: 22566526
Ann Intern Med. 2013 Feb 5;158(3):200-7
pubmed: 23295957
J Biol Chem. 1999 Dec 24;274(52):37060-9
pubmed: 10601264
Am J Clin Nutr. 1998 Aug;68(2):365-71
pubmed: 9701195
Biometals. 2018 Oct;31(5):821-834
pubmed: 29974287
Am J Clin Nutr. 2007 May;85(5):1301-6
pubmed: 17490966
Front Nutr. 2014 Sep 01;1:14
pubmed: 25988117
Nutrition. 2001 Feb;17(2):161, 163-5
pubmed: 11240347