Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury.
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
02 12 2020
02 12 2020
Historique:
received:
04
07
2020
revised:
03
10
2020
accepted:
19
10
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
4
12
2020
Statut:
aheadofprint
Résumé
Cognitive impairment is a key cause of disability after traumatic brain injury (TBI) but relationships with overall functioning in daily life are often modest. The aim is to examine cognition at different levels of function and identify domains associated with disability. 1554 patients with mild-to-severe TBI were assessed at 6 months post injury on the Glasgow Outcome Scale-Extended (GOSE), the Short Form-12v2 and a battery of cognitive tests. Outcomes across GOSE categories were compared using analysis of covariance adjusting for age, sex and education. Overall effect sizes were small to medium, and greatest for tests involving processing speed ( This large-scale study provides novel insights into cognitive performance at different levels of disability and highlights the importance of processing speed in function in daily life. At upper levels of outcome, any influence of cognition on overall function is markedly attenuated and differences in mental health are salient.
Identifiants
pubmed: 33268472
pii: jnnp-2020-324492
doi: 10.1136/jnnp-2020-324492
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Cecilia Åkerlund
(C)
Krisztina Amrein
(K)
Nada Andelic
(N)
Lasse Andreassen
(L)
Audny Anke
(A)
Anna Antoni
(A)
Gérard Audibert
(G)
Philippe Azouvi
(P)
Maria Luisa Azzolini
(ML)
Ronald Bartels
(R)
Pál Barzó
(P)
Romuald Beauvais
(R)
Ronny Beer
(R)
Bo-Michael Bellander
(BM)
Antonio Belli
(A)
Habib Benali
(H)
Maurizio Berardino
(M)
Luigi Beretta
(L)
Morten Blaabjerg
(M)
Peter Bragge
(P)
Alexandra Brazinova
(A)
Vibeke Brinck
(V)
Joanne Brooker
(J)
Camilla Brorsson
(C)
Andras Buki
(A)
Monika Bullinger
(M)
Manuel Cabeleira
(M)
Alessio Caccioppola
(A)
Emiliana Calappi
(E)
Maria Rosa Calvi
(MR)
Peter Cameron
(P)
Guillermo Carbayo Lozano
(GC)
Marco Carbonara
(M)
Simona Cavallo
(S)
Giorgio Chevallard
(G)
Arturo Chieregato
(A)
Giuseppe Citerio
(G)
Iris Ceyisakar
(I)
Hans Clusmann
(H)
Mark Coburn
(M)
Jonathan Coles
(J)
Jamie D Cooper
(JD)
Marta Correia
(M)
Amra Čović
(A)
Nicola Curry
(N)
Endre Czeiter
(E)
Marek Czosnyka
(M)
Claire Dahyot-Fizelier
(C)
Paul Dark
(P)
Helen Dawes
(H)
Véronique De Keyser
(V)
Vincent Degos
(V)
Francesco Della Corte
(FD)
Hugo den Boogert
(HD)
Bart Depreitere
(B)
Đula Đilvesi
(Đ)
Abhishek Dixit
(A)
Emma Donoghue
(E)
Jens Dreier
(J)
Guy-Loup Dulière
(GL)
Ari Ercole
(A)
Patrick Esser
(P)
Erzsébet Ezer
(E)
Martin Fabricius
(M)
Valery L Feigin
(VL)
Kelly Foks
(K)
Shirin Frisvold
(S)
Alex Furmanov
(A)
Pablo Gagliardo
(P)
Damien Galanaud
(D)
Dashiell Gantner
(D)
Guoyi Gao
(G)
Pradeep George
(P)
Alexandre Ghuysen
(A)
Lelde Giga
(L)
Jagoš Golubovic Ben Glocker
(JG)
Pedro A Gomez
(PA)
Johannes Gratz
(J)
Benjamin Gravesteijn
(B)
Francesca Grossi
(F)
Russell L Gruen
(RL)
Deepak Gupta
(D)
Juanita A Haagsma
(JA)
Iain Haitsma
(I)
Raimund Helbok
(R)
Eirik Helseth
(E)
Lindsay Horton
(L)
Jilske Huijben
(J)
PeterJ Hutchinson
(P)
Bram Jacobs
(B)
Stefan Jankowski
(S)
Mike Jarrett
(M)
Ji-Yao Jiang
(JY)
Faye Johnson
(F)
Kelly Jones
(K)
Mladen Karan
(M)
Angelos G Kolias
(AG)
Erwin Kompanje
(E)
Daniel Kondziella
(D)
Evgenios Koraropoulos
(E)
Lars-Owe Koskinen
(LO)
Noémi Kovács
(N)
Ana Kowark
(A)
Alfonso Lagares
(A)
Linda Lanyon
(L)
Steven Laureys
(S)
Fiona Lecky
(F)
Didier Ledoux
(D)
Rolf Lefering
(R)
Valerie Legrand
(V)
Aurelie Lejeune
(A)
Leon Levi
(L)
Roger Lightfoot
(R)
Hester Lingsma
(H)
Andrew I R Maas
(AIR)
Ana M Castaño-León
(AM)
Marc Maegele
(M)
Marek Majdan
(M)
Alex Manara
(A)
Geoffrey Manley
(G)
Costanza Martino
(C)
Hugues Maréchal
(H)
Julia Mattern
(J)
Catherine McMahon
(C)
Béla Melegh
(B)
David Menon
(D)
Tomas Menovsky
(T)
Ana Mikolic
(A)
Benoit Misset
(B)
Visakh Muraleedharan
(V)
Lynnette Murray
(L)
Ancuta Negru
(A)
David Nelson
(D)
Virginia Newcombe
(V)
Daan Nieboer
(D)
József Nyirádi
(J)
Otesile Olubukola
(O)
Matej Oresic
(M)
Fabrizio Ortolano
(F)
Aarno Palotie
(A)
Paul M Parizel
(PM)
Jean-François Payen
(JF)
Natascha Perera
(N)
Vincent Perlbarg
(V)
Paolo Persona
(P)
Wilco Peul
(W)
Anna Piippo-Karjalainen
(A)
Matti Pirinen
(M)
Horia Ples
(H)
Suzanne Polinder
(S)
Inigo Pomposo
(I)
Jussi P Posti
(JP)
Louis Puybasset
(L)
Andreea Radoi
(A)
Arminas Ragauskas
(A)
Rahul Raj
(R)
Malinka Rambadagalla
(M)
Jonathan Rhodes
(J)
Sylvia Richardson
(S)
Sophie Richter
(S)
Samuli Ripatti
(S)
Saulius Rocka
(S)
Cecilie Roe
(C)
Olav Roise
(O)
Jonathan Rosand
(J)
Jeffrey V Rosenfeld
(JV)
Christina Rosenlund
(C)
Guy Rosenthal
(G)
Rolf Rossaint
(R)
Sandra Rossi
(S)
Daniel Rueckert
(D)
Martin Rusnák
(M)
Juan Sahuquillo
(J)
Oliver Sakowitz
(O)
Renan Sanchez-Porras
(R)
Janos Sandor
(J)
Nadine Schäfer
(N)
Silke Schmidt
(S)
Herbert Schoechl
(H)
Guus Schoonman
(G)
Rico Frederik Schou
(RF)
Elisabeth Schwendenwein
(E)
Charlie Sewalt
(C)
Toril Skandsen
(T)
Peter Smielewski
(P)
Abayomi Sorinola
(A)
Emmanuel A Stamatakis
(EA)
Simon Stanworth
(S)
Robert Stevens
(R)
William Stewart
(W)
Ewout W Steyerberg
(EW)
Nino Stocchetti
(N)
Nina Sundström
(N)
Anneliese Synnot
(A)
Riikka Takala
(R)
Viktória Tamás
(V)
Tomas Tamosuitis
(T)
Mark Steven Taylor
(MS)
Braden Te Ao
(BT)
Olli Tenovuo
(O)
Alice Theadom
(A)
Matt Thomas
(M)
Dick Tibboel
(D)
Marjolein Timmers
(M)
Christos Tolias
(C)
Tony Trapani
(T)
Cristina Maria Tudora
(CM)
Peter Vajkoczy
(P)
Shirley Vallance
(S)
Egils Valeinis
(E)
Zoltán Vámos
(Z)
Mathieu van der Jagt
(MV)
Gregory Van der Steen
(GV)
Joukje van der Naalt
(J)
Jeroen T J M van Dijck
(JTJMV)
Thomas A van Essen
(TAV)
Wim Van Hecke
(WV)
Caroline van Heugten
(CV)
Dominique Van Praag
(DV)
Thijs Vande Vyvere
(TV)
Roel P J van Wijk
(RPJV)
Alessia Vargiolu
(A)
Emmanuel Vega
(E)
Kimberley Velt
(K)
Jan Verheyden
(J)
Paul M Vespa
(PM)
Anne Vik
(A)
Rimantas Vilcinis
(R)
Victor Volovici
(V)
Nicole von Steinbüchel
(NV)
Daphne Voormolen
(D)
Petar Vulekovic
(P)
Kevin K W Wang
(KKW)
Eveline Wiegers
(E)
Guy Williams
(G)
Lindsay Wilson
(L)
Stefan Winzeck
(S)
Stefan Wolf
(S)
Zhihui Yang
(Z)
Peter Ylén
(P)
Alexander Younsi
(A)
Frederick A Zeiler
(FA)
Veronika Zelinkova
(V)
Agate Ziverte
(A)
Tommaso Zoerle
(T)
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: LW, LH, KK, NvS, DvP, AM and DM report funding from the EU FP7 programme during the course of the study. LW reports grants and personal fees from Vasopharm, outside the submitted work; BJS reports personal fees from Cassava Sciences, Greenfield BioVentures, and Cambridge Cognition, outside the submitted work; VFJN reports grants from Roche, outside the submitted work. DM reports grants, personal fees and non-financial support from GlaxoSmithKline, grants and personal fees from NeuroTrauma Sciences, Lantmannen AB and Integra Neurosciences, and personal fees from Pfizer, Calico and PressuraNeuro, outside the submitted work.