Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
18
05
2020
revised:
30
07
2020
accepted:
25
11
2020
pubmed:
4
12
2020
medline:
4
1
2022
entrez:
3
12
2020
Statut:
ppublish
Résumé
Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited. We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed ( Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46), with significant trends across categories of lifetime cumulative exposure and duration ( This study provides some evidence of an association between occupational heat exposure and female breast cancer risk. Our results contribute substantially to the scientific literature. Further investigations are needed considering multiple occupational exposures.
Sections du résumé
BACKGROUND
Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited.
METHODS
We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed (
RESULTS
Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46), with significant trends across categories of lifetime cumulative exposure and duration (
CONCLUSIONS
This study provides some evidence of an association between occupational heat exposure and female breast cancer risk.
IMPACT
Our results contribute substantially to the scientific literature. Further investigations are needed considering multiple occupational exposures.
Identifiants
pubmed: 33268491
pii: 1055-9965.EPI-20-0732
doi: 10.1158/1055-9965.EPI-20-0732
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-372Informations de copyright
©2020 American Association for Cancer Research.
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