Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury.
Animals
Disease Models, Animal
Disseminated Intravascular Coagulation
/ blood
Female
Fibrin Fibrinogen Degradation Products
/ analysis
Hepatocytes
/ transplantation
Humans
Liver Diseases
/ physiopathology
Macaca mulatta
Male
Mice, Inbred C57BL
Mice, Knockout
Viral Tropism
/ physiology
Yellow Fever
/ complications
Yellow fever virus
/ physiology
D-dimer
coagulopathy
hepatitis
pathogenesis
yellow fever virus
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 12 2020
22 12 2020
Historique:
pubmed:
4
12
2020
medline:
20
2
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Yellow fever (YF) is a mosquito-transmitted viral disease that causes tens of thousands of deaths each year despite the long-standing deployment of an effective vaccine. In its most severe form, YF manifests as a hemorrhagic fever that causes severe damage to visceral organs. Although coagulopathy is a defining feature of severe YF in humans, the mechanism by which it develops remains uncertain. Hepatocytes are a major target of yellow fever virus (YFV) infection, and the coagulopathy in severe YF has long been attributed to massive hepatocyte infection and destruction that results in a defect in clotting factor synthesis. However, when we analyzed blood from Brazilian patients with severe YF, we found high concentrations of plasma D-dimer, a fibrin split product, suggestive of a concurrent consumptive process. To define the relationship between coagulopathy and hepatocellular tropism, we compared infection and disease in
Identifiants
pubmed: 33268494
pii: 2014096117
doi: 10.1073/pnas.2014096117
pmc: PMC7768776
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
fibrin fragment D
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
32648-32656Subventions
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI073755
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB021955
Pays : United States
Organisme : NIAID NIH HHS
ID : R44 AI079898
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: M.S.D. is a consultant for Inbios, Eli Lilly, Vir Biotechnology, NGM Biopharmaceuticals, and is on the Scientific Advisory Board of Moderna and Immunome. The Diamond laboratory has received funding unrelated to this project under sponsored research agreements from Moderna, Vir Biotechnology, and Emergent BioSolutions.
Références
J Virol. 2019 Jun 28;93(14):
pubmed: 31043530
Nat Biotechnol. 2007 Aug;25(8):903-10
pubmed: 17664939
J Gen Virol. 1986 Apr;67 ( Pt 4):631-7
pubmed: 3958694
Arch Virol. 1983;76(1):51-61
pubmed: 6860148
J Clin Virol. 2015 Mar;64:160-73
pubmed: 25453327
J Gen Virol. 2015 Jun;96(Pt 6):1328-1339
pubmed: 25646269
J Infect Dis. 1999 Feb;179 Suppl 1:S199-202
pubmed: 9988185
Br J Haematol. 1969 Nov;17(5):455-62
pubmed: 4981419
Am J Trop Med Hyg. 1982 May;31(3 Pt 1):548-55
pubmed: 6177259
Vet Clin North Am Small Anim Pract. 2017 May;47(3):601-615
pubmed: 28034472
Circ Res. 2005 Jun 24;96(12):1233-9
pubmed: 15920023
J Travel Med. 2019 Jun 11;26(5):
pubmed: 31180486
PLoS Pathog. 2009 Oct;5(10):e1000614
pubmed: 19816561
Lancet Glob Health. 2018 Mar;6(3):e270-e278
pubmed: 29398634
PLoS Pathog. 2007 Sep 14;3(9):1262-70
pubmed: 17941708
Am J Trop Med Hyg. 1981 Mar;30(2):431-43
pubmed: 7235133
Nat Commun. 2017 Mar 14;8:14781
pubmed: 28290449
J Travel Med. 2019 Jun 11;26(5):
pubmed: 31150098
Sci Rep. 2019 Dec 31;9(1):20418
pubmed: 31892699
Front Biosci (Landmark Ed). 2011 Jun 01;16(9):3196-215
pubmed: 21622229
Sci Rep. 2020 Feb 21;10(1):3180
pubmed: 32081931
Lancet Infect Dis. 2019 Jul;19(7):750-758
pubmed: 31104909
J Exp Med. 1937 May 31;65(6):787-800
pubmed: 19870634
Am J Clin Pathol. 1955 Feb;25(2):135-46
pubmed: 14349922
Genes (Basel). 2018 Jun 08;9(6):
pubmed: 29890711
Am J Trop Med Hyg. 2018 Jun;98(6):1833-1836
pubmed: 29611509
Trends Microbiol. 2018 Nov;26(11):913-928
pubmed: 29933925
Curr Opin Immunol. 2015 Oct;36:38-46
pubmed: 26163194
J Infect Dis. 2001 May 15;183(10):1431-6
pubmed: 11319679
J Virol. 2001 Nov;75(22):10912-22
pubmed: 11602731
Lancet. 2018 Dec 1;392(10162):2347
pubmed: 30527606
Clin Exp Immunol. 2002 Apr;128(1):163-8
pubmed: 11982604
Hepatology. 2005 Apr;41(4):847-56
pubmed: 15791625
J Virol. 2006 Dec;80(24):12149-59
pubmed: 17035317
Am J Trop Med Hyg. 2010 Jul;83(1):183-8
pubmed: 20595499
Science. 1930 Apr 4;71(1840):367
pubmed: 17731835
Emerg Microbes Infect. 2016 Jul 13;5(7):e69
pubmed: 27406389
Virology. 2005 Nov 25;342(2):167-76
pubmed: 16150475
Virus Res. 2013 Aug;175(2):155-9
pubmed: 23639427
Lancet Infect Dis. 2017 Nov;17(11):1209-1217
pubmed: 28822780
NPJ Vaccines. 2018 Jan 23;3:5
pubmed: 29387474
PLoS One. 2012;7(9):e41707
pubmed: 23028428
J Infect Dis. 2014 Aug 15;210(4):558-66
pubmed: 24526742
Virology. 2011 Mar 30;412(1):188-95
pubmed: 21277609
J Exp Med. 1931 Sep 30;54(4):533-55
pubmed: 19869938
Nature. 2019 Aug;572(7768):199-204
pubmed: 31292543
Virology. 2003 Sep 30;314(2):662-70
pubmed: 14554093
Am J Trop Med Hyg. 1982 Jul;31(4):830-6
pubmed: 6285749
Am J Trop Med Hyg. 2006 Jun;74(6):1084-9
pubmed: 16760525
PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3295
pubmed: 25412185
Adv Virus Res. 2003;60:343-95
pubmed: 14689698
J Gen Virol. 1996 Jun;77 ( Pt 6):1277-85
pubmed: 8683217
Thromb Res. 2011 Aug;128(2):103-16
pubmed: 21215993
J Thromb Haemost. 2007 Apr;5(4):670-9
pubmed: 17403201
Rev Med Virol. 2008 Sep-Oct;18(5):331-46
pubmed: 18615782
J Infect Dis. 2003 Dec 1;188(11):1618-29
pubmed: 14639531
J Virol. 1996 Apr;70(4):2208-14
pubmed: 8642644
J Gen Virol. 2011 Oct;92(Pt 10):2262-2271
pubmed: 21697351
Appl Microbiol. 1973 Apr;25(4):539-44
pubmed: 4633476