Mossy Cells in the Dorsal and Ventral Dentate Gyrus Differ in Their Patterns of Axonal Projections.
associational pathway
commissural pathway
dentate granule cells
hilus
hippocampus
mossy cells
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
03 02 2021
03 02 2021
Historique:
received:
16
09
2020
revised:
08
11
2020
accepted:
20
11
2020
pubmed:
4
12
2020
medline:
29
4
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Mossy cells (MCs) of the dentate gyrus (DG) are a major group of excitatory hilar neurons that are important for regulating activity of dentate granule cells. MCs are particularly intriguing because of their extensive longitudinal connections within the DG. It has generally been assumed that MCs in the dorsal and ventral DG have similar patterns of termination in the inner one-third of the dentate molecular layer. Here, we demonstrate that axonal projections of MCs in these two regions are considerably different. MCs in dorsal and ventral regions were labeled selectively with Cre-dependent eYFP or mCherry, using two transgenic mouse lines (including both sexes) that express Cre-recombinase in MCs. At four to six weeks following unilateral labeling of MCs in the ventral DG, a dense band of fibers was present in the inner one-fourth of the molecular layer and extended bilaterally throughout the rostral-caudal extent of the DG, replicating the expected distribution of MC axons. In contrast, following labeling of MCs in the dorsal DG, the projections were more diffusely distributed. At the level of transfection, fibers were present in the inner molecular layer, but they progressively expanded into the middle molecular layer and, most ventrally, formed a distinct band in this region. Optical stimulation of these caudal fibers expressing ChR2 demonstrated robust EPSCs in ipsilateral granule cells and enhanced the effects of perforant path stimulation in the ventral DG. These findings suggest that MCs in the dorsal and ventral DG differ in the distribution of their axonal projections and possibly their function.
Identifiants
pubmed: 33268544
pii: JNEUROSCI.2455-20.2020
doi: 10.1523/JNEUROSCI.2455-20.2020
pmc: PMC7880284
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
991-1004Subventions
Organisme : NINDS NIH HHS
ID : R01 NS099137
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS030549
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG050474
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS030549
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102608
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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