Pistacia lentiscus extract enhances mammary epithelial cells' productivity by modulating their oxidative status.
Animals
Cattle
Cells, Cultured
Epithelial Cells
/ drug effects
Female
Glycolipids
/ metabolism
Glycoproteins
/ metabolism
Lactose
/ metabolism
Lipid Droplets
/ metabolism
Lipid Metabolism
/ drug effects
Mammary Glands, Animal
/ cytology
Oxidation-Reduction
/ drug effects
Oxygen Consumption
/ drug effects
Pistacia
/ chemistry
Plant Extracts
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 12 2020
02 12 2020
Historique:
received:
06
05
2020
accepted:
19
10
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
15
1
2021
Statut:
epublish
Résumé
We assessed the potential of phenolic compounds from Pistacia lentiscus (lentisk) to enhance production of milk constituents in bovine mammary epithelial cells (MEC). MEC were exposed to 0 (control), 1 or 10 ppm of polyphenols from lentisk ethanolic extract (PLEE) for 24 h. PLEE were absorbed by the MEC plasma membrane, but also penetrated the cell to accumulate in and around the nucleus. PLEE increased triglyceride content in the cell and its secretion to the medium, and significantly increased intracellular lipid droplet diameter. Compared to control, PLEE increased dose-dependently the lactose synthesis, secretion of whey proteins, and contents of casein. To evaluate mitochondrial activity under pro-oxidant load, MEC were preincubated with PLEE and exposed for 2 h to H
Identifiants
pubmed: 33268807
doi: 10.1038/s41598-020-78065-z
pii: 10.1038/s41598-020-78065-z
pmc: PMC7710751
doi:
Substances chimiques
Glycolipids
0
Glycoproteins
0
Plant Extracts
0
milk fat globule
0
Lactose
J2B2A4N98G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20985Références
J Cell Sci. 2011 Oct 1;124(Pt 19):3247-53
pubmed: 21878492
J Agric Food Chem. 2008 Nov 12;56(21):10063-70
pubmed: 18925742
Cell Death Dis. 2011 Aug 04;2:e189
pubmed: 21814287
Annu Rev Plant Biol. 2004;55:373-99
pubmed: 15377225
Antioxid Redox Signal. 2001 Dec;3(6):1147-52
pubmed: 11813988
Oxid Med Cell Longev. 2012;2012:976753
pubmed: 22829965
J Nutr. 2006 Oct;136(10):2468-74
pubmed: 16988111
Free Radic Biol Med. 2004 Sep 15;37(6):755-67
pubmed: 15304252
Toxicology. 2000 Nov 30;155(1-3):55-61
pubmed: 11154797
BMC Dev Biol. 2005 Dec 03;5:27
pubmed: 16324220
Vet Parasitol. 2013 Jan 16;191(1-2):44-50
pubmed: 22985927
J Mammary Gland Biol Neoplasia. 2017 Dec;22(4):235-249
pubmed: 29188493
PLoS One. 2013 Jun 14;8(6):e66092
pubmed: 23799073
Am J Clin Nutr. 2004 May;79(5):727-47
pubmed: 15113710
Nat Rev Mol Cell Biol. 2013 Dec;14(12):775-86
pubmed: 24220094
Trends Biochem Sci. 2010 Dec;35(12):669-75
pubmed: 20863707
J Agric Food Chem. 2005 Mar 23;53(6):2015-21
pubmed: 15769129
Molecules. 2012 Oct 26;17(11):12657-64
pubmed: 23103532
Vet Rec. 2000 Dec 16;147(25):703-8
pubmed: 11140928
Carcinogenesis. 1998 Oct;19(10):1771-6
pubmed: 9806157
PLoS One. 2018 Dec 31;13(12):e0209565
pubmed: 30596687
J Nutr Biochem. 2005 Oct;16(10):577-86
pubmed: 16111877
Free Radic Biol Med. 1995 Oct;19(4):481-6
pubmed: 7590397
In Vivo. 2012 Sep-Oct;26(5):777-85
pubmed: 22949590
J Dairy Sci. 2009 Jan;92(1):177-88
pubmed: 19109277
Food Chem. 2020 May 30;313:125822
pubmed: 31931419
J Cell Biol. 2004 Feb 2;164(3):341-6
pubmed: 14757749
Plant Methods. 2013 Oct 02;9(1):36
pubmed: 24083940
Curr Med Chem. 2010;17(28):3262-88
pubmed: 20666718
J Dairy Sci. 2005 Dec;88(12):4295-303
pubmed: 16291620
Free Radic Biol Med. 1994 Mar;16(3):405-9
pubmed: 8063204
Food Chem Toxicol. 2016 Sep;95:64-74
pubmed: 27375189
Chemosphere. 2019 Dec;236:124858
pubmed: 31549674
Free Radic Biol Med. 2014 Jan;66:36-44
pubmed: 23434765
J Dairy Sci. 2017 Aug;100(8):6229-6238
pubmed: 28551180
J Anim Sci. 2018 Sep 29;96(10):4159-4172
pubmed: 30032286
Exp Biol Med (Maywood). 2010 Jun;235(6):689-99
pubmed: 20511673
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Oxid Med Cell Longev. 2016;2016:2572175
pubmed: 26962394
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7789-94
pubmed: 24821780
Interdiscip Toxicol. 2012 Jun;5(2):47-58
pubmed: 23118587
Vet Immunol Immunopathol. 1995 Dec;49(3):263-70
pubmed: 8746700
Vet Immunol Immunopathol. 2009 Mar 15;128(1-3):104-9
pubmed: 19027173
Bioresour Technol. 2014;152:24-30
pubmed: 24275022
J Dairy Sci. 2008 Oct;91(10):4022-7
pubmed: 18832228
Biotechnology (N Y). 1995 Dec;13(13):1452-7
pubmed: 9636304
Nat Prod Bioprospect. 2014 Aug;4(4):227-31
pubmed: 25089241
Antimicrob Agents Chemother. 2007 Feb;51(2):551-9
pubmed: 17116667
PLoS One. 2015 Mar 10;10(3):e0121645
pubmed: 25756421
J Dairy Sci. 2019 Mar;102(3):2783-2795
pubmed: 30639008
EMBO Rep. 2009 Mar;10(3):194-200
pubmed: 19229284