Nonalcoholic fatty liver disease in lean subjects: Prognosis, outcomes and management.
Clinical outcomes
Disease management
Lean nonalcoholic fatty liver disease
Lifestyle interventions
Metabolic outcomes
Non-obese nonalcoholic fatty liver disease
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Nov 2020
14 Nov 2020
Historique:
received:
30
08
2020
revised:
24
09
2020
accepted:
20
10
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) accounts for most cases of chronic liver disease worldwide, with an estimated global prevalence of approximately 25% and ranges from simple steatosis to nonalcoholic steatohepatitis and cirrhosis. NAFLD is strongly connected to metabolic syndrome, and for many years, fatty liver was considered to be an exclusive feature of obese patients. However, recent studies have highlighted the presence of NAFLD in non-obese subjects, with or without increased visceral fat or even in lean subjects without increased waist circumference. "Lean NAFLD" is a relatively new concept and there is significant scientific interest in understanding the differences in pathophysiology, prognosis and management compared with NAFLD in overweight/obese patients. In the present editorial, we discuss the clinical and metabolic profiles and outcomes of lean NAFLD compared with both obese NAFLD and lean healthy individuals from Asian and Western countries. Moreover, we shed light to the challenging topic of management of NAFLD in lean subjects since there are no specific guidelines for this population. Finally, we discuss open questions and issues to be addressed in the future in order to categorize NAFLD patients into lean and non-lean cohorts.
Identifiants
pubmed: 33268944
doi: 10.3748/wjg.v26.i42.6514
pmc: PMC7673972
doi:
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
6514-6528Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors have no conflict of interest to disclose with respect to this review.
Références
Sci Rep. 2017 Jul 3;7(1):4492
pubmed: 28674415
PLoS One. 2014 Feb 03;9(2):e87523
pubmed: 24498332
Am J Clin Nutr. 2007 Aug;86(2):353-9
pubmed: 17684205
Clin Gastroenterol Hepatol. 2017 Apr;15(4):474-485
pubmed: 27581063
Lancet. 2004 Jan 10;363(9403):157-63
pubmed: 14726171
J Gastroenterol Hepatol. 2015 Nov;30(11):1666-72
pubmed: 25974139
JCI Insight. 2020 Mar 12;5(5):
pubmed: 32161197
J Hepatol. 2015 Nov;63(5):1229-37
pubmed: 26385766
Arch Med Sci Atheroscler Dis. 2019 Aug 06;4:e191-e195
pubmed: 31538123
World J Hepatol. 2016 Nov 28;8(33):1459-1465
pubmed: 27957244
Nat Commun. 2014 Jun 30;5:4309
pubmed: 24978903
Hepatology. 2017 Dec;66(6):1885-1893
pubmed: 28741298
Am J Gastroenterol. 2017 Jan;112(1):102-110
pubmed: 27527746
Br J Radiol. 2012 Oct;85(1018):e826-30
pubmed: 22514099
Hepatology. 2020 Jan;71(1):363-374
pubmed: 31230380
Hepatol Res. 2016 Sep;46(10):1011-8
pubmed: 26763865
Hepatol Int. 2019 May;13(3):314-322
pubmed: 30539516
J Zhejiang Univ Sci B. 2014 Oct;15(10):879-87
pubmed: 25294377
J Intern Med. 2020 Jul;288(1):139-151
pubmed: 32319718
Lancet. 2005 Sep 24-30;366(9491):1059-62
pubmed: 16182882
N Engl J Med. 2018 Mar 22;378(12):1096-1106
pubmed: 29562163
J Clin Gastroenterol. 2013 Mar;47(3):280-6
pubmed: 23391869
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20
pubmed: 28930295
J Hepatol. 2016 Jun;64(6):1388-402
pubmed: 27062661
Clin Nutr. 2019 Jun;38(3):975-981
pubmed: 30466956
J Hepatol. 2016 Dec;65(6):1263-1265
pubmed: 27520876
J Clin Med. 2018 Dec 17;7(12):
pubmed: 30562976
Hepatology. 2018 Jan;67(1):328-357
pubmed: 28714183
Liver Int. 2014 Apr;34(4):604-11
pubmed: 24382309
Scand J Gastroenterol. 2009;44(4):471-7
pubmed: 19058085
Hepatology. 2017 Jan;65(1):54-64
pubmed: 27339817
Am J Gastroenterol. 2015 Sep;110(9):1306-14; quiz 1315
pubmed: 26215532
Br J Nutr. 2017 Mar;117(5):662-668
pubmed: 28345499
Hepatology. 2015 Feb;61(2):506-14
pubmed: 25251399
Sci Rep. 2018 Mar 19;8(1):4788
pubmed: 29555959
Curr Pharm Des. 2018;24(38):4574-4586
pubmed: 30652642
World J Gastroenterol. 2020 Apr 21;26(15):1792-1804
pubmed: 32351294
Scand J Gastroenterol. 2015 Mar;50(3):341-6
pubmed: 25540973
Liver Int. 2016 Feb;36(2):275-83
pubmed: 26176710
Am J Clin Nutr. 2014 Mar;99(3):535-42
pubmed: 24401715
Dig Dis Sci. 2020 Jun;65(6):1850-1860
pubmed: 31724099
J Gastroenterol Hepatol. 2015 Jan;30(1):21-7
pubmed: 25167786
Liver Int. 2018 Dec;38(12):2277-2286
pubmed: 29851261
Medicine (Baltimore). 2012 Nov;91(6):319-27
pubmed: 23117851
Am J Gastroenterol. 2012 Dec;107(12):1852-8
pubmed: 23032980
Medicina (Kaunas). 2019 Sep 17;55(9):
pubmed: 31533345
J Hepatol. 2019 Oct;71(4):793-801
pubmed: 31279902
PLoS Med. 2004 Dec;1(3):e62
pubmed: 15602591
JHEP Rep. 2019 Aug 30;1(4):329-341
pubmed: 32039383
J Hepatol. 2013 Sep;59(3):550-6
pubmed: 23665288
J Gastroenterol Hepatol. 2016 Nov;31(11):1802-1807
pubmed: 27029776
PLoS One. 2018 Feb 9;13(2):e0192663
pubmed: 29425212
Indian J Gastroenterol. 2014 Sep;33(5):452-7
pubmed: 25023045
Nat Genet. 2008 Dec;40(12):1461-5
pubmed: 18820647
Menopause. 2015 Jun;22(6):667-73
pubmed: 25513983
World J Gastroenterol. 2014 Dec 21;20(47):17932-40
pubmed: 25548491
Eur J Endocrinol. 2019 Aug;181(2):185-192
pubmed: 31176297
Indian J Endocrinol Metab. 2013 Jul;17(4):665-71
pubmed: 23961483
Clin Gastroenterol Hepatol. 2017 Oct;15(10):1604-1611.e1
pubmed: 28554682
Liver Int. 2017 Jul;37(7):936-949
pubmed: 28371239
Clin Diabetes. 2019 Jan;37(1):65-72
pubmed: 30705499
J Hepatol. 2015 May;62(5):1148-55
pubmed: 25477264
J Gastroenterol. 2015 Jan;50(1):95-108
pubmed: 24619537
Eur J Gastroenterol Hepatol. 2020 Oct;32(10):1352-1357
pubmed: 32092046
Hepatobiliary Pancreat Dis Int. 2018 Feb;17(1):45-48
pubmed: 29428103
Atherosclerosis. 2009 Apr;203(2):581-6
pubmed: 18774133
Turk J Gastroenterol. 2014 Dec;25 Suppl 1:63-8
pubmed: 25910371
Hepatology. 2007 Apr;45(4):846-54
pubmed: 17393509
Obesity (Silver Spring). 2014 May;22(5):1345-50
pubmed: 24493150
Medicine (Baltimore). 2017 May;96(18):e6712
pubmed: 28471965
J Gastroenterol Hepatol. 2012 Aug;27(8):1341-7
pubmed: 22554085
Hepatol Commun. 2017 Nov 30;2(1):48-57
pubmed: 29404512
J Gastroenterol Hepatol. 2019 Jan;34(1):256-262
pubmed: 29949199
Hepatol Int. 2013 Jun;7(2):586-91
pubmed: 26201791
Dig Liver Dis. 2018 Apr;50(4):370-377
pubmed: 29398414
Lipids Health Dis. 2010 Mar 12;9:29
pubmed: 20222991
Lancet Gastroenterol Hepatol. 2020 Aug;5(8):739-752
pubmed: 32413340
Hepatology. 2020 Apr;71(4):1213-1227
pubmed: 31442319
Hepatology. 2006 Jun;43(6):1317-25
pubmed: 16729309