A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19.
COVID-19
immunomodulation
microbiome
mitochondrial dysfunction
photobiomodulation
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
17
08
2020
accepted:
01
09
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
4
12
2020
Statut:
epublish
Résumé
COVID-19 is an evolving pandemic that has far reaching global effects, with a combination of factors that makes the virus difficult to contain. The symptoms of infection can be devastating or at the least very debilitating for vulnerable individuals. It is clear that the elderly are at most risk of the adverse impacts of the virus, including hospitalization and death. Others at risk are those with comorbidities such as cardiovascular disease and metabolic conditions and those with a hyper-excitable immune response. Treatment options for those with acute responses to the virus are limited and there is an urgent need for potential strategies that can mitigate these severe effects. One potential avenue for treatment that has not been explored is the microbiome gut/lung axis. In addition to those severely affected by their acute reaction to the virus, there is also a need for treatment options for those that are slow to recover from the effects of the infection and also those who have been adversely affected by the measures put in place to arrest the spread of the virus. One potential treatment option is photobiomodulation (PBM) therapy. PBM has been shown over many years to be a safe, effective, non-invasive and easily deployed adjunctive treatment option for inflammatory conditions, pain, tissue healing and cellular energy. We have also recently demonstrated the effectiveness of PBM to alter the gut microbiome. PBM therapy is worthy of consideration as a potential treatment for those most vulnerable to COVID-19, such as the elderly and those with comorbidities. The treatment may potentially be advantageous for those infected with the virus, those who have a slow recovery from the effects of the virus and those who have been denied their normal exercise/rehabilitation programs due to the isolation restrictions that have been imposed to control the COVID-19 pandemic.
Identifiants
pubmed: 33269093
doi: 10.14336/AD.2020.0901
pii: ad-11-6-1352
pmc: PMC7673843
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1352-1362Informations de copyright
copyright: © 2020 Liebert et al.
Déclaration de conflit d'intérêts
Conflict of Interest AL, BB and WM are founders and employees of SYMBYX Pty Ltd, a medical technology company that develops photobiomodulation devices to treat metabolic and neurodegenerative conditions.
Références
Lancet Psychiatry. 2020 Oct;7(10):875-882
pubmed: 32593341
Lasers Surg Med. 1997;21(3):262-8
pubmed: 9291083
Photobiomodul Photomed Laser Surg. 2020 May;38(5):255-257
pubmed: 32326830
J Biophotonics. 2016 Dec;9(11-12):1273-1299
pubmed: 27874264
Lasers Med Sci. 2018 Dec;33(9):1875-1882
pubmed: 29797102
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Health Phys. 1989 May;56(5):691-704
pubmed: 2651364
Front Immunol. 2019 Jul 04;10:1551
pubmed: 31333675
J Cardiovasc Pharmacol. 2015 Dec;66(6):540-50
pubmed: 26322922
Lasers Surg Med. 2000;27(3):255-61
pubmed: 11013387
Oxid Med Cell Longev. 2018 Mar 4;2018:6798238
pubmed: 29686745
IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3):
pubmed: 28070154
Int J Mol Sci. 2017 Apr 28;18(5):
pubmed: 28452964
Nat Rev Immunol. 2016 May 27;16(6):341-52
pubmed: 27231050
Cell Res. 2020 Jun;30(6):492-506
pubmed: 32433595
Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):651-656
pubmed: 31647774
J Cardiovasc Electrophysiol. 2020 May;31(5):1003-1008
pubmed: 32270559
J Physiol. 2017 Jan 15;595(2):465-476
pubmed: 27426277
Anaesthesia. 2020 Aug;75(8):989-992
pubmed: 32397005
Curr Pharm Des. 2018;24(6):710-717
pubmed: 29345577
Exp Brain Res. 2017 Oct;235(10):3081-3092
pubmed: 28744621
Neuroscience. 2019 Dec 1;422:161-171
pubmed: 31682952
J Surg Res. 1994 Jun;56(6):537-42
pubmed: 8015308
Sci Rep. 2015 Jun 01;5:10581
pubmed: 26030745
BMJ. 2020 Mar 26;368:m1252
pubmed: 32217607
Cell Metab. 2014 Feb 4;19(2):178-80
pubmed: 24506863
Nat Med. 2014 Feb;20(2):159-66
pubmed: 24390308
PLoS One. 2013 Dec 11;8(12):e82899
pubmed: 24349390
Lasers Med Sci. 2018 Feb;33(2):343-351
pubmed: 29170901
J Neurol Sci. 2020 Jun 15;413:116832
pubmed: 32299017
Clin Dermatol. 2012 Jul-Aug;30(4):451-5
pubmed: 22855977
Brain Behav Immun. 2020 Jul;87:53-54
pubmed: 32311498
Arterioscler Thromb Vasc Biol. 2019 May;39(5):e146-e156
pubmed: 31017824
Metabolism. 2020 Jul;108:154247
pubmed: 32333939
BMJ. 2020 Mar 26;368:m1198
pubmed: 32217618
Aging (Albany NY). 2018 Sep 15;10(9):2224-2225
pubmed: 30219804
Med Hypotheses. 2020 Nov;144:109969
pubmed: 32592918
Lasers Med Sci. 2018 Apr;33(3):513-521
pubmed: 29181641
Photodermatol Photoimmunol Photomed. 2003 Aug;19(4):203-12
pubmed: 12925192
Sci Rep. 2017 Feb 09;7:42386
pubmed: 28181487
Photobiomodul Photomed Laser Surg. 2020 Jul;38(7):395-397
pubmed: 32579049
Photochem Photobiol. 2013 Jan-Feb;89(1):179-88
pubmed: 22882462
Arch Med Res. 2020 Oct;51(7):721-722
pubmed: 32471704
PLoS One. 2014 Jul 03;9(7):e101270
pubmed: 24991808
Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14857-14863
pubmed: 32527856
Br Dent J. 2020 Apr;228(8):569
pubmed: 32332938
Front Psychol. 2020 Sep 29;11:577740
pubmed: 33132987
Virus Res. 2020 Aug;285:198018
pubmed: 32430279
Nat Rev Immunol. 2020 May;20(5):271-272
pubmed: 32296135
J Perinatol. 2015 Jul;35(7):493-6
pubmed: 25695843
Inflammation. 2008 Jun;31(3):189-97
pubmed: 18421573
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
Clin Obes. 2020 Jun;10(3):e12365
pubmed: 32342637
SN Compr Clin Med. 2020;2(8):1019-1024
pubmed: 32838150
J Neurotrauma. 2014 Jun 1;31(11):1008-17
pubmed: 24568233
Lancet Psychiatry. 2020 Jul;7(7):611-627
pubmed: 32437679
Behav Brain Funct. 2009 Dec 08;5:46
pubmed: 19995444
Front Immunol. 2018 Aug 15;9:1830
pubmed: 30158926
Lasers Med Sci. 2019 Mar;34(2):317-327
pubmed: 30074108
Neurol Neuroimmunol Neuroinflamm. 2020 Jun 9;7(5):
pubmed: 32518172
Lasers Med Sci. 2017 Nov;32(8):1825-1834
pubmed: 28712048
Lancet Oncol. 2020 Mar;21(3):335-337
pubmed: 32066541
Lasers Med Sci. 2018 Aug;33(6):1197-1205
pubmed: 29455305
J Photochem Photobiol B. 2013 Mar 5;120:29-35
pubmed: 23416710
Nature. 2011 Jun 15;474(7351):327-36
pubmed: 21677749
Lasers Med Sci. 2016 Aug;31(6):1161-7
pubmed: 27220530
Lasers Surg Med. 2011 Jul;43(5):410-20
pubmed: 21674546
Am J Case Rep. 2020 Aug 15;21:e926779
pubmed: 32865522
Sci Rep. 2016 Aug 03;6:30540
pubmed: 27484673
J Biophotonics. 2016 Dec;9(11-12):1180-1188
pubmed: 27243910
J Endocrinol Invest. 2020 Aug;43(8):1053-1060
pubmed: 32495299
J Am Heart Assoc. 2020 Apr 7;9(7):e016219
pubmed: 32233755
Lasers Med Sci. 2020 Jul;35(5):1055-1063
pubmed: 31654154
FASEB J. 2020 Sep;34(9):11347-11354
pubmed: 33078484
Circulation. 2020 May 19;141(20):1648-1655
pubmed: 32200663
Ann Intern Med. 2020 May 05;172(9):577-582
pubmed: 32150748
Gastroenterology. 2020 Sep;159(3):944-955.e8
pubmed: 32442562
Lancet Microbe. 2020 Jul;1(3):e105
pubmed: 32835339
Sci Rep. 2019 Apr 19;9(1):6309
pubmed: 31004126
BBA Clin. 2016 Oct 01;6:113-124
pubmed: 27752476
Microb Biotechnol. 2012 Mar;5(2):226-32
pubmed: 21880118
Aging Dis. 2020 Jul 23;11(4):725-729
pubmed: 32765937
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S150-6
pubmed: 26595731
Dose Response. 2011;9(4):602-18
pubmed: 22461763
Front Immunol. 2019 Oct 25;10:2428
pubmed: 31708915
Endocrinology. 2007 Jun;148(6):2793-805
pubmed: 17363457
Cardiovasc Drugs Ther. 2021 Apr;35(2):205-214
pubmed: 32557011
Photobiomodul Photomed Laser Surg. 2020 May;38(5):258-259
pubmed: 32330404
J Med Virol. 2020 Jul;92(7):863-867
pubmed: 32297980
mSphere. 2020 Jun 24;5(3):
pubmed: 32581077
Expert Rev Clin Immunol. 2020 May;16(5):465-470
pubmed: 32237901
Lasers Med Sci. 2020 Mar;35(2):337-343
pubmed: 31152259
AIMS Biophys. 2017;4(3):337-361
pubmed: 28748217