Ipomoeassin-F inhibits the
Cell-free translation
ER membrane complex (EMC)
Endoplasmic reticulum (ER)
Sec61 translocon
viral protein biogenesis
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
05 Jan 2021
05 Jan 2021
Historique:
pubmed:
4
12
2020
medline:
4
12
2020
entrez:
3
12
2020
Statut:
epublish
Résumé
In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesised at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane protein synthesis at the ER is an attractive strategy for reducing the pathogenicity of SARS-CoV-2 and other obligate viral pathogens. Using an
Identifiants
pubmed: 33269350
doi: 10.1101/2020.11.24.390039
pmc: PMC7709170
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R15 GM116032
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing interests.