Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates.
Alzheimer's disease
diet
magnetic resonance imaging
non-human primate
psychological stress
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
12
10
2020
received:
18
06
2020
accepted:
19
10
2020
pubmed:
4
12
2020
medline:
11
11
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Associations between diet, psychosocial stress, and neurodegenerative disease, including Alzheimer's disease (AD), have been reported, but causal relationships are difficult to determine in human studies. We used structural magnetic resonance imaging in a well-validated non-human primate model of AD-like neuropathology to examine the longitudinal effects of diet (Mediterranean vs Western) and social subordination stress on brain anatomy, including global volumes, cortical thicknesses and volumes, and 20 individual regions of interest (ROIs). Western diet resulted in greater cortical thicknesses, total brain volumes, and gray matter, and diminished cerebrospinal fluid and white matter volumes. Socially stressed subordinates had smaller whole brain volumes but larger ROIs relevant to AD than dominants. The observation of increased size of AD-related brain areas is consistent with similar reports of mid-life volume increases predicting increased AD risk later in life. While the biological mechanisms underlying the findings require future investigation, these observations suggest that Western diet and psychosocial stress instigate pathologic changes that increase risk of AD-associated neuropathology, whereas the Mediterranean diet may protect the brain.
Identifiants
pubmed: 33270373
doi: 10.1002/alz.12232
pmc: PMC8119381
mid: NIHMS1689019
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
733-744Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL122393
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG033534
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK097748
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087103
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058829
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
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