The voiding efficiency in rat models with dopaminergic brain lesions induced through unilateral and bilateral intrastriatal injections.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
09
2020
accepted:
22
11
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
27
1
2021
Statut:
epublish
Résumé
Bladder dysfunction is a common phenomenon in Parkinson's disease (PD) patients. A research attempt was made to analyze the voiding efficiency (VE) and bladder functions in rats with PD induced by unilateral or bilateral injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. PD rats were divided into unilateral- and bilateral-injected groups and subjected to rotation and beam walking tests. Further, the experimental rats underwent cystometric measurements for analyses of bladder dysfunction and VE. Immunohistochemical analysis was performed to analyze the dopaminergic neuron depletion on the target area. Outcomes of the rotation and beam walking tests revealed the extent of parkinsonism in the experimental rats. Urodynamic observations denoted that rats with unilateral PD exhibited a significantly decreased VE (from 68.3±3.5% to 32.7±5.8%), while rats with bilateral PD displayed a much-reduced and substantially lower level of VE of 18.3±5.1% compared to the control value and to that of rats with unilateral PD. Rats with bilateral PD showed more-extensive behavioral deficits and urodynamic changes than did rats with unilateral PD. These significant changes in motor, behavioral, bladder function and VE were due to an extensive degeneration of dopaminergic neurons in the substantia nigra region on both sides of the brain. The obtained results were substantiated with appropriate immunohistochemical results.
Identifiants
pubmed: 33270757
doi: 10.1371/journal.pone.0243452
pii: PONE-D-20-28213
pmc: PMC7714362
doi:
Substances chimiques
Oxidopamine
8HW4YBZ748
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243452Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Neural Eng. 2016 Aug;13(4):046001
pubmed: 27187108
Mov Disord. 2012 Dec;27(14):1775-80
pubmed: 23080035
Clin Geriatr Med. 2020 Feb;36(1):69-80
pubmed: 31733703
Behav Brain Res. 2011 Sep 12;222(1):1-9
pubmed: 21435355
Int Urol Nephrol. 2019 Jan;51(1):41-52
pubmed: 30474784
Parkinsons Dis. 2019 Mar 5;2019:6820937
pubmed: 30949327
Behav Brain Res. 2006 Apr 25;169(1):1-9
pubmed: 16413939
Auton Neurosci. 2001 Sep 17;92(1-2):76-85
pubmed: 11570707
J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1382-6
pubmed: 21670077
Brain Res. 1994 Oct 31;662(1-2):69-74
pubmed: 7859092
Nat Rev Neurosci. 2008 Jun;9(6):453-66
pubmed: 18490916
Neurosci Lett. 2005 Jan 20;373(3):189-94
pubmed: 15619541
Front Neuroanat. 2014 Dec 15;8:155
pubmed: 25565980
Jpn J Pharmacol. 1979 Feb;29(1):93-104
pubmed: 459160
Appl Nurs Res. 2019 Dec;50:151193
pubmed: 31519495
Behav Neurosci. 1986 Feb;100(1):125-8
pubmed: 3082343
Acta Physiol Scand Suppl. 1971;367:95-122
pubmed: 4332694
J Neurol Neurosurg Psychiatry. 2000 Apr;68(4):429-33
pubmed: 10727477
Mov Disord. 2006 Jun;21(6):737-45
pubmed: 16570299
Neurosci Lett. 2007 Aug 9;423(1):12-7
pubmed: 17644250
Arq Neuropsiquiatr. 2003 Jun;61(2B):359-63
pubmed: 12894267
Mol Psychiatry. 2004 Jul;9(7):718-26
pubmed: 14699433
Clin Neurophysiol. 2002 Nov;113(11):1667-72
pubmed: 12417218
Brain Sci. 2019 Nov 14;9(11):
pubmed: 31739594
Brain Res. 2006 Nov 20;1120(1):202-10
pubmed: 16997286
J Neurosci Methods. 2005 May 15;144(1):35-45
pubmed: 15848237
Mol Neurodegener. 2013 Apr 26;8:14
pubmed: 23621954
J Neurosci Methods. 2007 Jan 30;159(2):195-202
pubmed: 16942799
Neurourol Urodyn. 2006;25(4):388-96
pubmed: 16637068
Neurourol Urodyn. 2011 Jan;30(1):188-93
pubmed: 20589898
J Urol. 2000 Nov;164(5):1640-3
pubmed: 11025724
Brain Res. 1991 Apr 19;546(2):310-20
pubmed: 1676929
Acta Physiol Scand Suppl. 1971;367:69-93
pubmed: 4332693
J Neurol Neurosurg Psychiatry. 1997 May;62(5):507-11
pubmed: 9153611