The case for an HIV cure and how to get there.


Journal

The lancet. HIV
ISSN: 2352-3018
Titre abrégé: Lancet HIV
Pays: Netherlands
ID NLM: 101645355

Informations de publication

Date de publication:
01 2021
Historique:
received: 06 05 2020
revised: 06 08 2020
accepted: 11 08 2020
pubmed: 4 12 2020
medline: 26 1 2021
entrez: 3 12 2020
Statut: ppublish

Résumé

In light of the increasing global burden of new HIV infections, growing financial requirements, and shifting funding landscape, the global health community must accelerate the development and delivery of an HIV cure to complement existing prevention modalities. An effective curative intervention could prevent new infections, overcome the limitations of antiretroviral treatment, combat stigma and discrimination, and provide a sustainable financial solution for pandemic control. We propose steps to plan for an HIV cure now, including defining a target product profile and establishing the HIV Cure Africa Acceleration Partnership (HCAAP), a multidisciplinary public-private partnership that will catalyse and promote HIV cure research through diverse stakeholder engagement. HCAAP will convene stakeholders, including people living with HIV, at an early stage to accelerate the design, social acceptability, and rapid adoption of HIV-cure products.

Identifiants

pubmed: 33271124
pii: S2352-3018(20)30232-0
doi: 10.1016/S2352-3018(20)30232-0
pmc: PMC7773626
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e51-e58

Subventions

Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Mark Dybul (M)

Center for Global Health Practice and Impact, Georgetown University, Washington, DC, USA. Electronic address: mrd54@georgetown.edu.

Timothy Attoye (T)

Global Health Division, The Bill & Melinda Gates Foundation, Seattle, WA, USA.

Solange Baptiste (S)

International Treatment Preparedness Coalition, Johannesburg, South Africa.

Peter Cherutich (P)

Kenya Ministry of Health, Nairobi, Kenya.

François Dabis (F)

Agence Nationale de Recherches sur le SIDA et les Hepatites Virales, Paris, France.

Steven G Deeks (SG)

University of California, San Francisco, California, USA.

Carl Dieffenbach (C)

Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.

Brian Doehle (B)

Global Health Division, The Bill & Melinda Gates Foundation, Seattle, WA, USA.

Maureen M Goodenow (MM)

Office of AIDS Research, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.

Adam Jiang (A)

McKinsey & Company Secondee at The Bill & Melinda Gates Foundation, Seattle, WA, USA.

Dominic Kemps (D)

Sommartel, London, UK.

Sharon R Lewin (SR)

Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.

Murray M Lumpkin (MM)

Global Health Division, The Bill & Melinda Gates Foundation, Seattle, WA, USA.

Lauren Mathae (L)

Center for Global Health Practice and Impact, Georgetown University, Washington, DC, USA.

Joseph M McCune (JM)

Global Health Division, The Bill & Melinda Gates Foundation, Seattle, WA, USA.

Thumbi Ndung'u (T)

Africa Health Research Institute, Durban, South Africa; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban South Africa; Max Planck Institute for Infection Biology, Berlin, Germany; University College London, London, UK.

Moses Nsubuga (M)

Joint Adherent Brothers & Sisters Against AIDS, Kampala, Uganda.

Holly L Peay (HL)

RTI International, Research Triangle Park, NC, USA.

John Pottage (J)

Viiv Healthcare, Brentford, UK.

Mitchell Warren (M)

AIDS Vaccine Advocacy Coalition, New York, NY, USA.

Izukanji Sikazwe (I)

Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.

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Classifications MeSH