Altered circadian dynamics of Per2 after cystathionine-β-synthase and/or cystathionine-γ-lyase pharmacological inhibition in serum-shocked NIH-3T3 cells.
Animals
Cell Survival
/ drug effects
Circadian Rhythm
/ drug effects
Cystathionine beta-Synthase
/ antagonists & inhibitors
Cystathionine gamma-Lyase
/ antagonists & inhibitors
Dose-Response Relationship, Drug
Enzyme Inhibitors
/ pharmacology
Gene Expression Regulation
/ drug effects
Gene Knockdown Techniques
Mice
NIH 3T3 Cells
Period Circadian Proteins
/ metabolism
RNA, Small Interfering
/ genetics
Serum
/ metabolism
Circadian clock
Cystathionine-β-synthase
Cystathionine-γ-lyase
L-cysteine
Period2
Journal
Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
01
08
2020
revised:
14
11
2020
accepted:
26
11
2020
pubmed:
4
12
2020
medline:
2
2
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Circadian clock genes are found in almost every cell that has a nucleus; they regulate the rhythmic nature of all processes that are cyclical. Among the genes controlled by the circadian clock, there are numerous factors that regulate key processes in the functioning of the cell. Disturbances in the functioning of the circadian clock are associated with numerous disorders. A recent study has shown the key role of H
Identifiants
pubmed: 33271147
pii: S0003-9861(20)30722-0
doi: 10.1016/j.abb.2020.108713
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Per2 protein, mouse
0
Period Circadian Proteins
0
RNA, Small Interfering
0
Cystathionine beta-Synthase
EC 4.2.1.22
Cystathionine gamma-Lyase
EC 4.4.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108713Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.