Antimicrobial, cytotoxicity, molecular modeling and DNA cleavage/binding studies of zinc-naproxen complex: switching DNA binding mode of naproxen by coordination to zinc ion.
DNA cleavage
DNA interaction
MTT assay
Zinc-naproxen complex
groove binding
molecular docking
Journal
Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
pubmed:
5
12
2020
medline:
21
5
2022
entrez:
4
12
2020
Statut:
ppublish
Résumé
The intercalation DNA binding mode of the naproxen, a non-steroidal anti-inflammatory drug, has been reported previously. In this study, calf thymus deoxyribonucleic acid (CT-DNA) binding of zinc-naproxen complex, [Zn(naproxen)
Identifiants
pubmed: 33272098
doi: 10.1080/07391102.2020.1854858
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Coordination Complexes
0
Naproxen
57Y76R9ATQ
DNA
9007-49-2
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM