Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease.
Aged
Aged, 80 and over
Carotid Artery Diseases
/ epidemiology
Chromatography, Gas
Endarterectomy, Carotid
Erythrocyte Membrane
/ chemistry
Erythrocytes
/ chemistry
Fatty Acids
/ blood
Fatty Acids, Omega-3
/ blood
Female
Humans
Linoleic Acid
/ metabolism
Male
Phospholipids
/ blood
Plaque, Atherosclerotic
Prevalence
alpha-linolenic acid
carotid endarterectomy
dietary fats
docosahexaenoic acid
phospholipids
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
pubmed:
5
12
2020
medline:
15
12
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease. We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography. In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022-0.607], Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.
Sections du résumé
BACKGROUND AND PURPOSE
The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease.
METHODS
We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography.
RESULTS
In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022-0.607],
CONCLUSIONS
Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.
Identifiants
pubmed: 33272124
doi: 10.1161/STROKEAHA.120.030477
doi:
Substances chimiques
Fatty Acids
0
Fatty Acids, Omega-3
0
Phospholipids
0
Linoleic Acid
9KJL21T0QJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM