A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities.
Animals
Antioxidants
/ chemical synthesis
Biomarkers
/ blood
Brain
Chalcogens
/ chemistry
Drug Evaluation, Preclinical
Free Radical Scavengers
/ chemical synthesis
Free Radicals
/ metabolism
Glutathione Peroxidase
/ metabolism
Green Chemistry Technology
/ methods
Humans
Kidney
Liver
Male
Mice
Organophosphonates
/ chemical synthesis
Oxidation-Reduction
Selenium Compounds
/ chemistry
Solvents
/ chemistry
Structure-Activity Relationship
Superoxide Dismutase
/ metabolism
Tellurium
/ chemistry
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
03
09
2020
revised:
17
11
2020
accepted:
22
11
2020
pubmed:
5
12
2020
medline:
1
5
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
In this contribution, a metal- and base-free protocol has been developed for the synthesis of phosphorochalcogenoates (Se and Te) by using DMSO as solvent at 50 °C. A variety of phosphorochalcogenoates were prepared from diorganyl dichalcogenides and H-phosphonates, leading to the formation of a Chal-P(O) bond, in a rapid procedure with good to excellent yields. A full structural elucidation of products was accessed by 1D and 2D NMR, IR, CGMS, and HRMS analyses, and a stability evaluation of the phosphorochalcogenoates was performed for an effective operational description of this simple and feasible method. Typical
Identifiants
pubmed: 33272781
pii: S0223-5234(20)31024-2
doi: 10.1016/j.ejmech.2020.113052
pii:
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
Chalcogens
0
Free Radical Scavengers
0
Free Radicals
0
Organophosphonates
0
Selenium Compounds
0
Solvents
0
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Tellurium
NQA0O090ZJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113052Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.