Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.
Adult
Asian People
/ genetics
Bayes Theorem
Case-Control Studies
China
/ epidemiology
Asia, Eastern
/ ethnology
Female
Genetic Loci
/ genetics
Genetic Predisposition to Disease
/ epidemiology
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Japan
/ epidemiology
Lupus Erythematosus, Systemic
/ epidemiology
Male
Middle Aged
Prevalence
Republic of Korea
/ epidemiology
epidemiology
genetic
lupus erythematosus
polymorphism
systemic
Journal
Annals of the rheumatic diseases
ISSN: 1468-2060
Titre abrégé: Ann Rheum Dis
Pays: England
ID NLM: 0372355
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
30
09
2020
revised:
04
11
2020
accepted:
11
11
2020
pubmed:
5
12
2020
medline:
11
9
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations. We newly genotyped 10 029 SLE cases and 180 167 controls and subsequently meta-analysed them jointly with 3348 SLE cases and 14 826 controls from published studies in East Asians. We further applied a Bayesian statistical approach to localise the putative causal variants for SLE associations. We identified 113 genetic regions including 46 novel loci at genome-wide significance (p<5×10 This study reiterates the power of large-scale genome-wide meta-analysis for novel genetic discovery. These findings shed light on genetic and biological understandings of SLE.
Identifiants
pubmed: 33272962
pii: annrheumdis-2020-219209
doi: 10.1136/annrheumdis-2020-219209
pmc: PMC8053352
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
632-640Subventions
Organisme : NIAID NIH HHS
ID : R01 AI024717
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073228
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.