Pathology of Uddanam Endemic Nephropathy.
CKDu
Chronic interstitial nephritis
renal pathology
Journal
Indian journal of nephrology
ISSN: 0971-4065
Titre abrégé: Indian J Nephrol
Pays: India
ID NLM: 8914356
Informations de publication
Date de publication:
Historique:
received:
20
11
2018
revised:
28
03
2019
accepted:
07
05
2019
entrez:
4
12
2020
pubmed:
5
12
2020
medline:
5
12
2020
Statut:
ppublish
Résumé
In the last decade, pockets of endemic nephropathy have been recognized worldwide, in regions of Central America, Sri Lanka, and India. In India, the nephropathy has been recognized in the Uddanam area of north Andhra Pradesh and has been termed the Uddanam endemic nephropathy (UEN). The disease is distinctive in that besides the geographic distribution, it affects rural populations engaged in farm labor and agriculture, often silent in the initial phase with most patients presenting with advanced renal failure. The renal biopsy findings in all geographic areas including UEN have been one of a chronic tubulointerstitial nephritis with varying degrees of tubular injury, interstitial inflammation, tubular atrophy, and interstitial fibrosis with nonspecific glomerular obsolescence and lack of immune deposits. More recently, the demonstration of dysmorphic lysosomes in renal biopsies has favored a toxic etiology. There are thus many gaps in the understanding of this serious disease prevalent among poorer populations.
Identifiants
pubmed: 33273789
doi: 10.4103/ijn.IJN_363_18
pii: IJN-30-253
pmc: PMC7699660
doi:
Types de publication
Journal Article
Langues
eng
Pagination
253-255Informations de copyright
Copyright: © 2019 Indian Journal of Nephrology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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