Effects of Chronic Ethanol Consumption and Ovariectomy on the Spontaneous Alveolar Bone Loss in Rats.
Journal
International journal of dentistry
ISSN: 1687-8728
Titre abrégé: Int J Dent
Pays: Egypt
ID NLM: 101524183
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
04
2020
revised:
03
09
2020
accepted:
21
10
2020
entrez:
4
12
2020
pubmed:
5
12
2020
medline:
5
12
2020
Statut:
epublish
Résumé
Postmenopausal estrogen deficiency and ethanol (EtOH) abuse are known risk factors for different diseases including bone tissues. However, little is known about the synergic effects of EtOH abuse and estrogen deficiency on alveolar bone loss in women. The present study evaluated the effects of EtOH chronic exposure and ovariectomy on the alveolar bone loss in female rats. For this, 40 female Wistar rats were randomly divided into 4 groups: control, EtOH exposure, ovariectomy (OVX), and OVX plus EtOH exposure. Initially, half of the animals were ovariectomized at 75 days of age. After that, the groups received distilled water or EtOH 6.5 g/kg/day (20% w/v) for 55 days via gavage. Thereafter, animals were sacrificed and the mandibles were collected, dissected, and separated into hemimandibles. Alveolar bone loss was evaluated by measuring the distance between the cementoenamel junction and the alveolar bone crest through a stereomicroscope in 3 different anatomical regions of the tissue. One-way ANOVA and post hoc Tukey were used to compare groups (
Identifiants
pubmed: 33273924
doi: 10.1155/2020/8873462
pmc: PMC7676921
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8873462Informations de copyright
Copyright © 2020 Priscila Cunha Nascimento et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Steroids. 2015 Jul;99(Pt A):11-5
pubmed: 25555470
Endocrinology. 1996 Feb;137(2):469-78
pubmed: 8593791
Alcohol. 2003 Apr;29(3):165-71
pubmed: 12798972
Alcohol Clin Exp Res. 2014 Mar;38(3):672-82
pubmed: 24256560
J Psychopharmacol. 2015 Jun;29(6):712-24
pubmed: 25922423
PLoS One. 2014 Jun 26;9(6):e101074
pubmed: 24967633
J Clin Exp Dent. 2018 Sep 01;10(9):e852-e857
pubmed: 30386516
Bone. 2010 Mar;46(3):806-12
pubmed: 19879987
J Clin Invest. 2000 Oct;106(7):887-95
pubmed: 11018077
Alcohol Res. 2013;35(2):219-28
pubmed: 24881330
Neurotoxicology. 2009 Jan;30(1):23-30
pubmed: 19100288
Mol Med Rep. 2015 Sep;12(3):3508-3514
pubmed: 26044123
Biomed Pharmacother. 1990;44(4):205-8
pubmed: 2397280
Front Behav Neurosci. 2018 May 15;12:88
pubmed: 29867389
Oral Dis. 2014 Jul;20(5):514-20
pubmed: 23919414
Chem Biol Interact. 2013 Apr 25;203(2):486-501
pubmed: 23376407
J Addict Nurs. 2016 Jul-Sep;27(3):205-13
pubmed: 27580194
J Periodontal Res. 2009 Dec;44(6):695-703
pubmed: 19453856
Zygote. 2013 May;21(2):158-61
pubmed: 22475413
Indian J Exp Biol. 2015 Feb;53(2):93-7
pubmed: 25757239
Tissue Cell. 2018 Dec;55:77-82
pubmed: 30503063
Oxid Med Cell Longev. 2016;2016:7323627
pubmed: 27579155
J Periodontal Res. 2002 Apr;37(2):161-5
pubmed: 12009186
Arch Oral Biol. 2014 Apr;59(4):424-33
pubmed: 24549089
Alcohol Res Health. 2001;25(4):276-81
pubmed: 11910705
J Bone Miner Res. 2009 Feb;24(2):221-30
pubmed: 18847333
Arthritis Rheum. 2006 Aug;54(8):2441-51
pubmed: 16871544
J Periodontal Res. 2006 Dec;41(6):527-34
pubmed: 17076777
J Transl Med. 2014 Oct 01;12:284
pubmed: 25269614
Neuroscience. 2011 Dec 29;199:333-45
pubmed: 22033458
Biomed Res Int. 2015;2015:635023
pubmed: 26060817
Public Health. 2008 Apr;122(4):417-33
pubmed: 18028967
Braz J Psychiatry. 2019 Mar-Apr;41(2):131-137
pubmed: 30365669
Clin Oral Investig. 2016 Apr;20(3):581-8
pubmed: 26179986
J Bone Miner Res. 2000 Dec;15(12):2504-12
pubmed: 11127216
Addiction. 2017 Jan;112 Suppl 1:94-101
pubmed: 27922203
Arch Oral Biol. 2012 Oct;57(10):1385-94
pubmed: 22595623
Mol Med Rep. 2015 Sep;12(3):3494-3502
pubmed: 26035209
Alcohol Alcohol. 2014 Mar-Apr;49(2):198-206
pubmed: 24302160
Braz Oral Res. 2011 Jan-Feb;25(1):80-4
pubmed: 21271178
Front Physiol. 2018 Aug 14;9:1098
pubmed: 30246792
Osteoporos Int. 1999;10(1):34-40
pubmed: 10501777