Hepatitis C virus in Iran; transmission routes, growth in 3a genotype distribution, and lack of liver marker relation with genotypes.
Genotype
Iran
hepatitis C virus
transmission
Journal
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
ISSN: 1735-1995
Titre abrégé: J Res Med Sci
Pays: India
ID NLM: 101235599
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
08
2019
revised:
24
02
2020
accepted:
27
05
2020
entrez:
4
12
2020
pubmed:
5
12
2020
medline:
5
12
2020
Statut:
epublish
Résumé
The hepatitis C virus (HCV) outbreak in Iran is increasing. This study investigated the dissemination and transmission routes of HCV genotypes in different regions of Iran. The relationship between serum biochemical markers and viral genotypes was also assessed to find whether liver enzymes level can be considered as the markers for HCV genotypes. HCV-infected patients from different provinces of Iran (from August 2017 to March 2019) were enrolled. Nested reverse transcriptase polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time PCR were used to discover the genotypes. The infection transmission routes in the study population were investigated and recorded. Serum samples with equal viral loud from the patients without other liver disorders were recruited to explore the association between the genotypes and the liver biochemical markers. One thousand serum samples positive for the HCV genome were recruited. Genotype 3a was the most prevalent in the north, while genotype 1a was dominant at the center. In total, genotype 3a was the dominant genotype closely followed by 1a. Needle sharing by addicts was the most common transmission way of infection in Iran. This way was also the most for genotype 3a dissemination, and genotype 1a was transmitted mostly between family members. No significant association ( A shift in the distribution profile of HCV genotypes, related to the transmission routes, has happened over time. Public awareness of the main routes of HCV transmission can break the cycle of transmission. Liver enzyme values in HCV-infected patients showed no relation with genotypes and only represented hepatocellular dysfunction.
Sections du résumé
BACKGROUND
BACKGROUND
The hepatitis C virus (HCV) outbreak in Iran is increasing. This study investigated the dissemination and transmission routes of HCV genotypes in different regions of Iran. The relationship between serum biochemical markers and viral genotypes was also assessed to find whether liver enzymes level can be considered as the markers for HCV genotypes.
MATERIALS AND METHODS
METHODS
HCV-infected patients from different provinces of Iran (from August 2017 to March 2019) were enrolled. Nested reverse transcriptase polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time PCR were used to discover the genotypes. The infection transmission routes in the study population were investigated and recorded. Serum samples with equal viral loud from the patients without other liver disorders were recruited to explore the association between the genotypes and the liver biochemical markers.
RESULTS
RESULTS
One thousand serum samples positive for the HCV genome were recruited. Genotype 3a was the most prevalent in the north, while genotype 1a was dominant at the center. In total, genotype 3a was the dominant genotype closely followed by 1a. Needle sharing by addicts was the most common transmission way of infection in Iran. This way was also the most for genotype 3a dissemination, and genotype 1a was transmitted mostly between family members. No significant association (
CONCLUSION
CONCLUSIONS
A shift in the distribution profile of HCV genotypes, related to the transmission routes, has happened over time. Public awareness of the main routes of HCV transmission can break the cycle of transmission. Liver enzyme values in HCV-infected patients showed no relation with genotypes and only represented hepatocellular dysfunction.
Identifiants
pubmed: 33273941
doi: 10.4103/jrms.JRMS_482_19
pii: JRMS-25-96
pmc: PMC7698380
doi:
Types de publication
Journal Article
Langues
eng
Pagination
96Informations de copyright
Copyright: © 2020 Journal of Research in Medical Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
East Mediterr Health J. 2012 Mar;18(3):236-40
pubmed: 22574476
J Hepatol. 2006;44(1 Suppl):S19-24
pubmed: 16356583
World J Hepatol. 2015 Jun 8;7(10):1377-89
pubmed: 26052383
Pak J Med Sci. 2013 Sep;29(5):1142-6
pubmed: 24353708
Virol J. 2013 Mar 20;10:90
pubmed: 23514695
Arch Iran Med. 2012 May;15(5):268
pubmed: 22519372
World J Gastroenterol. 2015 Oct 14;21(38):10790-810
pubmed: 26478671
J Res Med Sci. 2013 Aug;18(8):674-82
pubmed: 24379843
Virol J. 2011 Jun 10;8:293
pubmed: 21663629
Braz J Microbiol. 2016 Oct - Dec;47(4):980-986
pubmed: 27528079
J Infect Dis. 1995 Jun;171(6):1607-10
pubmed: 7769300
Postgrad Med J. 2016 Apr;92(1086):223-34
pubmed: 26842972
J Viral Hepat. 2012 Apr;19(4):229-35
pubmed: 22404720
Transfusion. 2009 Oct;49(10):2214-20
pubmed: 19527477
Int J Infect Dis. 2010 Sep;14 Suppl 3:e113-6
pubmed: 20362479
J Hepatol. 2006 Oct;45(4):529-38
pubmed: 16879891
Int J Infect Dis. 2006 Jul;10(4):272-7
pubmed: 16564719
PLoS One. 2013 Dec 02;8(12):e82230
pubmed: 24312645
J Infect Dis. 2013 Mar;207 Suppl 1:S7-S12
pubmed: 23390305
Hepat Mon. 2013 Jan;13(1):e7991
pubmed: 23550108
J Res Med Sci. 2018 Oct 26;23:87
pubmed: 30505325
Semin Liver Dis. 2011 Nov;31(4):340-6
pubmed: 22189974
Clin Diagn Virol. 1996 Oct;7(1):7-16
pubmed: 9077432
J Transl Int Med. 2017 Mar 31;5(1):8-17
pubmed: 28680834