Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature.
Journal
Case reports in hematology
ISSN: 2090-6560
Titre abrégé: Case Rep Hematol
Pays: United States
ID NLM: 101576456
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
07
2020
revised:
29
10
2020
accepted:
30
10
2020
entrez:
4
12
2020
pubmed:
5
12
2020
medline:
5
12
2020
Statut:
epublish
Résumé
Lenalidomide is indicated in the front-line management of multiple myeloma. More recently, it has been introduced for use in treating other hematologic malignancies. Although the drug is known to cause myelosuppression, there have been rare reports of lenalidomide-associated immune thrombocytopenia (ITP). Here, we review the literature on lenalidomide-associated ITP and report upon a 59-year-old man who was administered lenalidomide due to concern of progressive multiple myeloma more than a year following his having undergone an autologous hematopoietic stem cell transplant. His platelet count precipitously declined and lead to his hospitalization. Despite our withholding of the drug, he did not respond to platelet transfusions or administration of corticosteroids. He was successfully managed with intermittent immune globulin for several months before definitive treatment with splenectomy, which resulted in the complete resolution of his thrombocytopenia. A literature search identified a total of six additional cases of lenalidomide-associated ITP. Similarly, many of the reported cases were associated with persistent thrombocytopenia after discontinuation of the drug. Furthermore, these patients were generally managed successfully with standard ITP therapies, such as corticosteroids or intravenous immune globulin.
Identifiants
pubmed: 33274089
doi: 10.1155/2020/8825618
pmc: PMC7676979
doi:
Types de publication
Case Reports
Langues
eng
Pagination
8825618Informations de copyright
Copyright © 2020 William Forehand III et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Int J Hematol. 2013 Jul;98(1):24-33
pubmed: 23702914
Ann Intern Med. 1998 Dec 1;129(11):886-90
pubmed: 9867731
Semin Hematol. 2000 Jul;37(3):229-38
pubmed: 10942217
Case Rep Hematol. 2011;2011:638020
pubmed: 22937309
Blood. 2009 Jun 25;113(26):6511-21
pubmed: 19395674
J Natl Compr Canc Netw. 2018 May;16(5S):624-627
pubmed: 29784741
J Thromb Haemost. 2009 Jun;7(6):911-8
pubmed: 19344362
Oncologist. 2018 Jun;23(6):734-739
pubmed: 29438096
Br J Haematol. 2009 Apr;145(2):235-44
pubmed: 19245432
Blood. 2014 Nov 20;124(22):3308-15
pubmed: 25305203