Peanut-induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry.

Adolescent Anaphylaxis / diagnosis Arachis Child Epinephrine Humans Peanut Hypersensitivity / diagnosis Registries

anaphylaxis food allergy paediatrics

Journal

Allergy

ISSN: 1398-9995

Titre abrégé: Allergy

Pays: Denmark

ID NLM: 7804028

Informations de publication

Date de publication:
05 2021

Historique:

revised: 26 10 2020

received: 05 08 2020

accepted: 10 11 2020

pubmed: 5 12 2020

medline: 22 5 2021

entrez: 4 12 2020

Statut: ppublish

Résumé

Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%-1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents. Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre. 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004). The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.

Sections du résumé

BACKGROUND

METHODS

Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre.

RESULTS

3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004).

CONCLUSIONS

The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.

Identifiants

DOI: 10.1111/all.14683 PMID: 33274436

pubmed: 33274436

doi: 10.1111/all.14683

doi:

Substances chimiques

Epinephrine YKH834O4BH

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1517-1527

Investigateurs

J Grünhagen (J)

M Wittenberg (M)

K Beyer (K)

A Henschel (A)

S Küper (S)

A Möser (A)

T Fuchs (T)

F Ruëff (F)

B Wedi (B)

G Hansen (G)

T Buck (T)

J Büsselberg (J)

R Drägerdt (R)

L Pfeffer (L)

H Dickel (H)

C Körner-Rettberg (C)

H Merk (H)

S Lehmann (S)

A Bauer (A)

A Nordwig (A)

S Zeil (S)

C Hannapp (C)

N Wagner (N)

E Rietschel (E)

N Hunzelmann (N)

I Huseynow (I)

R Treudler (R)

S Aurich (S)

F Prenzel (F)

L Klimek (L)

O Pfaar (O)

N Reider (N)

W Aberer (W)

E Varga (E)

B Bogatu (B)

P Schmid-Grendelmeier (P)

R Guggenheim (R)

F Riffelmann (F)

B Kreft (B)

K Kinaciyan (K)

L Hartl (L)

C Ebner (C)

F Horak (F)

R Brehler (R)

J Witte (J)

M Buss (M)

S Hompes (S)

T Bieber (T)

S Gernert (S)

M Bücheler (M)

U Rabe (U)

W Brosi (W)

S Nestoris (S)

T Hawranek (T)

R Lang (R)

R Bruns (R)

C Pföhler (C)

P Eng (P)

S Schweitzer-Krantz (S)

S Meller (S)

H Rebmann (H)

J Fischer (J)

G Stichtenoth (G)

S Thies (S)

M Gerstlauer (M)

P Utz (P)

I Neustädter (I)

J Klinge (J)

S Volkmuth (S)

S Plank-Habibi (S)

B Schilling (B)

A Kleinheinz (A)

A Brückner (A)

K Schäkel (K)

I Manolaraki (I)

M Kowalski (M)

K Solarewicz-Madajek (K)

S Tscheiller (S)

J Seidenberg (J)

V Cardona (V)

B Garcia (B)

M Bilo (M)

N Cabañes Higuero (N)

A Vega Castro (A)

I Poziomkowska-Gęsicka (I)

S Büsing (S)

C Virchow (C)

G Christoff (G)

U Jappe (U)

S Müller (S)

F Knöpfel (F)

A-K Correard (AK)

B Rogala (B)

A Montoro (A)

A Brandes (A)

A Muraro (A)

N Zimmermann (N)

D Hernandez (D)

P Minale (P)

J Niederwimmer (J)

B Zahel (B)

L Dahdah (L)

S Arasi (S)

A Reissig (A)

F Eitelberger (F)

R Asero (R)

F Hermann (F)

S Zeidler (S)

S Pistauer (S)

M Geißler (M)

L Ensina (L)

A Plaza Martin (A)

J Meister (J)

S Stieglitz (S)

E Hamelmann (E)

Informations de copyright

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