Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.
Aging
/ physiology
Animals
Anthocyanins
/ pharmacology
Aorta, Thoracic
/ drug effects
Cellular Senescence
/ drug effects
Endothelium, Vascular
/ drug effects
Human Umbilical Vein Endothelial Cells
Humans
Male
Morus
/ chemistry
Nitric Oxide
/ biosynthesis
Nitric Oxide Synthase Type III
/ metabolism
Oxidative Stress
/ drug effects
Plant Extracts
/ pharmacology
Rats
Rats, Sprague-Dawley
Sirtuin 1
/ metabolism
Uncoupling Agents
/ pharmacology
NO
SIRT1
anthocyanins
eNOS deacetylation
senescence
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
06
2020
revised:
09
09
2020
accepted:
23
09
2020
pubmed:
5
12
2020
medline:
4
9
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
Endothelial dysfunction is one of the main age-related arterial phenotypes responsible for cardiovascular disease (CVD) in older adults. This endothelial dysfunction results from decreased bioavailability of nitric oxide (NO) arising downstream of endothelial oxidative stress. In this study, we investigated the protective effect of anthocyanins and the underlying mechanism in rat thoracic aorta and human vascular endothelial cells in aging models. In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-β-galactosidase activity, p21, and p16
Identifiants
pubmed: 33274583
doi: 10.1111/acel.13279
pmc: PMC7744959
doi:
Substances chimiques
Anthocyanins
0
Plant Extracts
0
Uncoupling Agents
0
cyanidin-3-O-beta-glucopyranoside
0
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type III
EC 1.14.13.39
Nos3 protein, rat
EC 1.14.13.39
Sirt1 protein, rat
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
cyanidin 3-rutinoside
OR49FC491X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13279Informations de copyright
© 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Références
Nitric Oxide. 2012 Feb 15;26(2):111-7
pubmed: 22245451
Free Radic Biol Med. 2005 Aug 1;39(3):327-35
pubmed: 15993331
EMBO J. 2004 Jun 16;23(12):2369-80
pubmed: 15152190
Am J Physiol Heart Circ Physiol. 2013 Jul 15;305(2):H251-8
pubmed: 23666675
J Clin Invest. 2013 Mar;123(3):946-50
pubmed: 23454756
Biochem Biophys Res Commun. 2012 Nov 2;427(4):701-4
pubmed: 23022527
Nitric Oxide. 2013 Aug 1;32:29-35
pubmed: 23583951
Cell Rep. 2014 Mar 13;6(5):836-43
pubmed: 24582957
Biogerontology. 2019 Dec;20(6):763-782
pubmed: 31538262
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
pubmed: 21890489
Nutrients. 2019 Apr 28;11(5):
pubmed: 31035424
Circulation. 2002 Apr 2;105(13):1541-4
pubmed: 11927518
Circulation. 2013 Jan 22;127(3):386-96
pubmed: 23224247
J Mol Cell Cardiol. 2015 Dec;89(Pt B):122-35
pubmed: 25655936
J Physiol. 2011 Sep 15;589(Pt 18):4545-54
pubmed: 21746786
Cardiovasc Res. 2008 Nov 1;80(2):191-9
pubmed: 18689793
Cell. 2005 Feb 25;120(4):513-22
pubmed: 15734683
Front Physiol. 2019 Sep 12;10:1173
pubmed: 31572218
Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2205-11
pubmed: 20705918
Pharmacol Ther. 2008 Dec;120(3):333-9
pubmed: 18930078
Circulation. 2006 Apr 4;113(13):1708-14
pubmed: 16585403
Trends Endocrinol Metab. 2014 Mar;25(3):138-45
pubmed: 24388149
Cytotechnology. 2018 Dec;70(6):1519-1528
pubmed: 30155610
Oxid Med Cell Longev. 2009 Nov-Dec;2(5):270-8
pubmed: 20716914
Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20
pubmed: 19429820
Biomed Pharmacother. 2018 Jan;97:1164-1172
pubmed: 29136955
Aging (Albany NY). 2016 Oct 15;8(10):2290-2307
pubmed: 27744418
Circulation. 2013 Nov 19;128(21):2318-24
pubmed: 24092817
J Vasc Res. 2010;47(4):287-98
pubmed: 20016203
Physiol Rev. 2002 Jan;82(1):47-95
pubmed: 11773609
Nutrients. 2018 Dec 28;11(1):
pubmed: 30597847
Biochem J. 2001 Aug 1;357(Pt 3):593-615
pubmed: 11463332
Antioxid Redox Signal. 2000 Winter;2(4):919-35
pubmed: 11213492
Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R1-12
pubmed: 12482742
Free Radic Biol Med. 2005 Jan 15;38(2):262-70
pubmed: 15607909
PLoS One. 2018 Aug 14;13(8):e0202051
pubmed: 30106986
Pharmacol Biochem Behav. 2014 May;120:7-16
pubmed: 24495488
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14855-60
pubmed: 17785417
Mol Cell Biol. 1999 Mar;19(3):2109-17
pubmed: 10022898
Biochem Pharmacol. 2013 May 1;85(9):1288-96
pubmed: 23422569
Clin Pharmacol Ther. 2013 Jan;93(1):105-16
pubmed: 23212104
Diabetes Res Clin Pract. 2010 Jul;89(1):38-45
pubmed: 20398956