Preleukemic and leukemic evolution at the stem cell level.


Journal

Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509

Informations de publication

Date de publication:
25 02 2021
Historique:
received: 03 08 2020
accepted: 01 12 2020
pubmed: 5 12 2020
medline: 23 7 2021
entrez: 4 12 2020
Statut: ppublish

Résumé

Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and relapse. We highlight recent advances and unanswered questions about the contribution of the hematopoietic stem cell population to these processes.

Identifiants

pubmed: 33275656
pii: S0006-4971(21)00377-3
doi: 10.1182/blood.2019004397
pmc: PMC7907728
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1013-1018

Subventions

Organisme : NCI NIH HHS
ID : P30 CA013330
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA217092
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007288
Pays : United States

Informations de copyright

© 2021 by The American Society of Hematology.

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Auteurs

Jacob Stauber (J)

Albert Einstein College of Medicine-Montefiore Health System, The Bronx, NY.

John M Greally (JM)

Albert Einstein College of Medicine-Montefiore Health System, The Bronx, NY.

Ulrich Steidl (U)

Albert Einstein College of Medicine-Montefiore Health System, The Bronx, NY.

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