The predictive power of CD3

Adult CD3 Complex / metabolism Diabetes Mellitus, Type 2 / epidemiology Glucose Transporter Type 1 / metabolism Humans Immunohistochemistry Kaplan-Meier Estimate Lymphocytes, Tumor-Infiltrating / immunology Male Middle Aged Monocarboxylic Acid Transporters / metabolism Mouth Mucosa / immunology Mouth Neoplasms / immunology Predictive Value of Tests Prognosis Risk Assessment / methods Risk Factors Squamous Cell Carcinoma of Head and Neck / immunology Symporters / metabolism T-Lymphocytes / immunology Warburg Effect, Oncologic
Diabetes mellitus Metabolism OSCC Prognosis TIL

Journal

Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053

Informations de publication

Date de publication:
28 02 2021
Historique:
received: 07 09 2020
revised: 04 11 2020
accepted: 21 11 2020
pubmed: 5 12 2020
medline: 21 5 2021
entrez: 4 12 2020
Statut: ppublish

Résumé

Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers such as lactate dehydrogenase (LDH) A or monocarboxylate transporter (MCT) 1 were increased in tumor samples from patients with diabetes and these patients had a significantly worse prognosis compared to non-diabetic patients. Analyses of immune cell infiltration in tumors from diabetic and non-diabetic patients revealed an increased leukocyte (CD45

Identifiants

DOI: 10.1016/j.canlet.2020.11.029 PMID: 33276040
pubmed: 33276040
pii: S0304-3835(20)30628-5
doi: 10.1016/j.canlet.2020.11.029
pii:
doi:

Substances chimiques

CD3 Complex 0
Glucose Transporter Type 1 0
Monocarboxylic Acid Transporters 0
SLC2A1 protein, human 0
Symporters 0
monocarboxylate transport protein 1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

209-219

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Gerrit Spanier (G)

Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053, Regensburg, Germany.

Ines Ugele (I)

Department of Otorhinolaryngology, University Hospital Regensburg, 93053, Regensburg, Germany.

Felix Nieberle (F)

Regensburg Center for Interventional Immunology, University of Regensburg, 93053, Regensburg, Germany.

Luisa Symeou (L)

Department of Otorhinolaryngology, University Hospital Regensburg, 93053, Regensburg, Germany.

Sandra Schmidhofer (S)

Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany.

Almut Brand (A)

Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany.

Johannes Meier (J)

Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053, Regensburg, Germany.

Steffen Spoerl (S)

Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053, Regensburg, Germany.

Rosemarie Krupar (R)

Institute of Pathology, University Hospital Regensburg, 93053, Regensburg, Germany.

Petra Rümmele (P)

Institute of Pathology, University Hospital Regensburg, 93053, Regensburg, Germany.

Peter Siska (P)

Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany.

Kathrin Renner (K)

Regensburg Center for Interventional Immunology, University of Regensburg, 93053, Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany.

Katrin Peter (K)

Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany.

Michael Gerken (M)

Tumor Center - Institute for Quality Management and Health Services Research, University of Regensburg, 93053, Regensburg, Germany.

Philipp Beckhove (P)

Regensburg Center for Interventional Immunology, University of Regensburg, 93053, Regensburg, Germany.

Torsten E Reichert (TE)

Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053, Regensburg, Germany.

Marina Kreutz (M)

Regensburg Center for Interventional Immunology, University of Regensburg, 93053, Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany. Electronic address: marina.kreutz@ukr.de.

Katrin Singer (K)

Department of Otorhinolaryngology, University Hospital Regensburg, 93053, Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, 93053, Regensburg, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The predictive power of CD3
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD3 › The predictive power of CD3
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › The predictive power of CD3
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de glucose par diffusion facilitée › Transporteur de glucose de type 1 › The predictive power of CD3
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The predictive power of CD3
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › The predictive power of CD3
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Estimation de Kaplan-Meier › The predictive power of CD3
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › The predictive power of CD3
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The predictive power of CD3
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'acides monocarboxyliques › The predictive power of CD3
questionsmedicales.fr › Système stomatognathique › Bouche › Muqueuse de la bouche › The predictive power of CD3
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Tumeurs de la bouche › The predictive power of CD3
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › The predictive power of CD3
questionsmedicales.fr › Diagnostic › Pronostic › The predictive power of CD3
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › The predictive power of CD3
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The predictive power of CD3
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › The predictive power of CD3
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › The predictive power of CD3
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › The predictive power of CD3
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Effet Warburg en oncologie › The predictive power of CD3