Age-related DNA methylation changes are sex-specific: a comprehensive assessment.
ATPases Associated with Diverse Cellular Activities
/ genetics
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aging
/ genetics
CpG Islands
DNA Methylation
Databases, Genetic
Down Syndrome
/ diagnosis
Epigenesis, Genetic
Female
Humans
Longevity
/ genetics
Male
Microtubule-Associated Proteins
/ genetics
Middle Aged
Proline-Rich Protein Domains
Sex Factors
Young Adult
meta-analysis
methylation
sex
variability
whole blood
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
03 12 2020
03 12 2020
Historique:
received:
30
07
2020
accepted:
19
10
2020
pubmed:
5
12
2020
medline:
28
4
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
The existence of a sex gap in human health and longevity has been widely documented. Autosomal DNA methylation differences between males and females have been reported, but so far few studies have investigated if DNA methylation is differently affected by aging in males and females. We performed a meta-analysis of 4 large whole blood datasets, comparing 4 aspects of epigenetic age-dependent remodeling between the two sexes: differential methylation, variability, epimutations and entropy. We reported that a large fraction (43%) of sex-associated probes undergoes age-associated DNA methylation changes, and that a limited number of probes show age-by-sex interaction. We experimentally validated 2 regions mapping in
Identifiants
pubmed: 33276343
pii: 202251
doi: 10.18632/aging.202251
pmc: PMC7762479
doi:
Substances chimiques
Microtubule-Associated Proteins
0
ATPases Associated with Diverse Cellular Activities
EC 3.6.4.-
FIGN protein, human
EC 3.6.4.-
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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