Covert Cognition in Disorders of Consciousness: A Meta-Analysis.
cognitive motor dissociation
consciousness
covert cognition
minimally conscious state
severe brain injury
vegetative state
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
02 Dec 2020
02 Dec 2020
Historique:
received:
01
10
2020
revised:
16
11
2020
accepted:
24
11
2020
entrez:
5
12
2020
pubmed:
6
12
2020
medline:
6
12
2020
Statut:
epublish
Résumé
Covert cognition in patients with disorders of consciousness represents a real diagnostic conundrum for clinicians. In this meta-analysis, our main objective was to identify clinical and demographic variables that are more likely to be associated with responding to an active paradigm. Among 2018 citations found on PubMed, 60 observational studies were found relevant. Based on the QUADAS-2, 49 studies were considered. Data from 25 publications were extracted and included in the meta-analysis. Most of these studies used electrophysiology as well as counting tasks or mental imagery. According to our statistical analysis, patients clinically diagnosed as being in a vegetative state and in a minimally conscious state minus (MCS-) show similar likelihood in responding to active paradigm and responders are most likely suffering from a traumatic brain injury. In the future, multi-centric studies should be performed in order to increase sample size, with similar methodologies and include structural and functional neuroimaging in order to identify cerebral markers related to such a challenging diagnosis.
Identifiants
pubmed: 33276451
pii: brainsci10120930
doi: 10.3390/brainsci10120930
pmc: PMC7759773
pii:
doi:
Types de publication
Journal Article
Langues
eng
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