Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.
Adolescent
Adult
Aged
Aging
/ genetics
DNA Damage
/ genetics
DNA, Mitochondrial
/ genetics
Female
Homeostasis
/ genetics
Humans
Iron
/ metabolism
Iron-Binding Proteins
/ metabolism
Male
Membrane Transport Proteins
/ metabolism
Mitochondria
/ genetics
Mitochondrial Proteins
/ genetics
Muscle, Skeletal
/ metabolism
Young Adult
Frataxin
autophagy
iron dyshomeostasis
iron isotopes
iron metabolism
mitochondria
mitochondrial quality control
mitophagy
muscle aging
oxidative stress
physical performance
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 12 2020
02 12 2020
Historique:
received:
18
11
2020
accepted:
30
11
2020
entrez:
5
12
2020
pubmed:
6
12
2020
medline:
24
6
2021
Statut:
epublish
Résumé
Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from young and older adults. The expression of key proteins of mitochondrial quality control (MQC) and the abundance of the mitochondrial DNA common deletion (mtDNA
Identifiants
pubmed: 33276460
pii: cells9122579
doi: 10.3390/cells9122579
pmc: PMC7760001
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Iron-Binding Proteins
0
Membrane Transport Proteins
0
Mitochondrial Proteins
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Références
Exp Gerontol. 2008 Jun;43(6):563-70
pubmed: 18395385
Diabetes. 2003 Aug;52(8):1888-96
pubmed: 12882902
Biomolecules. 2018 Dec 17;8(4):
pubmed: 30563025
J Gerontol. 1994 Mar;49(2):M85-94
pubmed: 8126356
Exp Gerontol. 2012 Jan;47(1):38-44
pubmed: 22015325
Int J Mol Sci. 2017 Aug 28;18(9):
pubmed: 28846632
PLoS One. 2012;7(2):e32829
pubmed: 22389725
Annu Rev Med. 2011;62:347-60
pubmed: 20887198
J Am Geriatr Soc. 2004 Dec;52(12):2094-8
pubmed: 15571549
Metallomics. 2011 Sep;3(9):926-33
pubmed: 21789323
Exp Gerontol. 2012 Jan;47(1):100-8
pubmed: 22085543
Clin Geriatr Med. 2009 Nov;25(4):715-32, ix
pubmed: 19944269
Mol Cell Biol. 2017 Feb 15;37(5):
pubmed: 27956698
Sci Rep. 2017 Nov 20;7(1):15879
pubmed: 29158487
Science. 2004 Jul 9;305(5681):242-5
pubmed: 15247478
Int J Mol Sci. 2017 Apr 28;18(5):
pubmed: 28452964
J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):223-9
pubmed: 19182232
Aging Cell. 2012 Oct;11(5):801-9
pubmed: 22681576
Liver Int. 2016 Feb;36(2):246-57
pubmed: 26077449
Biomed Pharmacother. 2001 Jul;55(6):333-9
pubmed: 11478586
Ageing Res Rev. 2004 Jul;3(3):303-18
pubmed: 15231238
Biochim Biophys Acta. 2008 Sep;1777(9):1092-7
pubmed: 18519024
Nat Rev Cardiol. 2018 Sep;15(9):543-554
pubmed: 30042431
PLoS One. 2008 Aug 06;3(8):e2865
pubmed: 18682742
J Am Geriatr Soc. 2020 Jul;68(7):1476-1483
pubmed: 32196636
Muscle Nerve. 2007 Aug;36(2):223-33
pubmed: 17503500
Exp Gerontol. 2020 Oct 15;140:111048
pubmed: 32755612
Front Med (Lausanne). 2014 Sep 01;1:27
pubmed: 25593902
Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):506-16
pubmed: 16677095
Curr Biol. 2015 Jul 20;25(14):1810-22
pubmed: 26144971
Free Radic Biol Med. 2018 Aug 20;124:447-453
pubmed: 29969715
Nat Med. 2018 Jun;24(6):770-781
pubmed: 29875463
BMC Med. 2016 Dec 22;14(1):215
pubmed: 28003033
Biomolecules. 2015 May 11;5(2):808-47
pubmed: 25970586
Exp Gerontol. 2017 Oct 1;96:63-67
pubmed: 28602957
J Biol Chem. 2009 Jan 9;284(2):711-5
pubmed: 18757363
Rejuvenation Res. 2018 Aug;21(4):350-359
pubmed: 29125070
Aging Cell. 2008 Oct;7(5):706-16
pubmed: 18843794
J Clin Med. 2020 May 12;9(5):
pubmed: 32408624
Int J Mol Sci. 2020 May 28;21(11):
pubmed: 32481481
Cells. 2020 Apr 15;9(4):
pubmed: 32326435
Cell Metab. 2015 Feb 3;21(2):311-323
pubmed: 25651183
JAMA. 2011 Jan 5;305(1):50-8
pubmed: 21205966
Mech Ageing Dev. 2010 Jul-Aug;131(7-8):487-93
pubmed: 20434480
Biochim Biophys Acta. 2015 Jun;1853(6):1493-512
pubmed: 25245479
Expert Opin Ther Targets. 2019 Feb;23(2):153-160
pubmed: 30580640
Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5618-23
pubmed: 15800038
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Exp Physiol. 2008 Mar;93(3):407-14
pubmed: 17981932
Blood. 2007 Jul 1;110(1):401-8
pubmed: 17379741
Nat Commun. 2020 Jul 16;11(1):3570
pubmed: 32678081
J Clin Med. 2020 Feb 12;9(2):
pubmed: 32059608
Mech Ageing Dev. 2009 Apr;130(4):272-80
pubmed: 19396981
J Am Geriatr Soc. 2020 Apr;68(4):872-881
pubmed: 32105353
Int J Hematol. 2008 Jul;88(1):7-15
pubmed: 18594779
Cells. 2019 Nov 27;8(12):
pubmed: 31783583
Int J Mol Sci. 2019 Feb 13;20(4):
pubmed: 30781825
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):447-55
pubmed: 23051977
Cells. 2020 Mar 03;9(3):
pubmed: 32138154
Science. 2004 Dec 17;306(5704):2090-3
pubmed: 15514116
Age (Dordr). 2013 Oct;35(5):1607-20
pubmed: 22945739
Exp Gerontol. 2018 Nov;113:48-57
pubmed: 30261246
Free Radic Biol Med. 2020 Nov 20;160:680-689
pubmed: 32911084
Exp Gerontol. 2017 Nov;98:99-109
pubmed: 28807823
Hum Mol Genet. 2017 Jun 15;26(12):2192-2206
pubmed: 28369518
J Neural Transm (Vienna). 2020 Feb;127(2):189-203
pubmed: 31912279
Am J Prev Med. 2019 Jan;56(1):141-146
pubmed: 30573142
Sci Rep. 2015 Dec 07;5:18132
pubmed: 26638758
N Engl J Med. 1995 Mar 2;332(9):556-61
pubmed: 7838189
Int J Mol Sci. 2019 May 27;20(10):
pubmed: 31137890
JAMA. 2014 Jun 18;311(23):2387-96
pubmed: 24866862