Glia in Neurodegeneration: The Housekeeper, the Defender and the Perpetrator.
astrocytes
human
microglia
mouse
neurodegeneration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Dec 2020
02 Dec 2020
Historique:
received:
19
10
2020
revised:
23
11
2020
accepted:
26
11
2020
entrez:
5
12
2020
pubmed:
6
12
2020
medline:
10
3
2021
Statut:
epublish
Résumé
Over the past decade, research has unveiled the intimate relationship between neuroinflammation and neurodegeneration. Microglia and astrocytes react to brain insult by setting up a multimodal inflammatory state and act as the primary defenders and executioners of neuroinflammatory structural and functional changes. Microglia and astrocytes also play critical roles in the maintenance of normal brain function. This intricate balance of homeostatic and neuroinflammatory functions can influence the onset and the course of neurodegenerative diseases. The emergent role of the microglial-astrocytic axis in neurodegenerative disease presents many druggable targets that may have broad therapeutic benefits across neurodegenerative disease. Here, we provide a brief review of the basal function of both microglia and astrocytes, how they are changed in disease states, the significant differences between mouse and human glia, and use of human induced pluripotent stem cells derived from patients to study cell autonomous changes in human astrocytes and microglia.
Identifiants
pubmed: 33276471
pii: ijms21239188
doi: 10.3390/ijms21239188
pmc: PMC7730416
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS107387
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109077
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS105604
Pays : United States
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