Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson's Disease.
Aged
Aged, 80 and over
Disease Progression
Dopaminergic Neurons
/ metabolism
Female
Humans
Male
Melanins
/ metabolism
Metalloendopeptidases
/ metabolism
Methionine-tRNA Ligase
/ metabolism
Mitochondria
/ metabolism
Parkinson Disease
/ metabolism
Proteome
/ metabolism
Proteomics
/ methods
Substantia Nigra
/ metabolism
Synaptosomes
/ metabolism
Thymidine Kinase
/ metabolism
Parkinson’s disease
mitochondrial pathology
mitochondrial translation
proteomics
substantia nigra pars compacta
synaptosomes
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 12 2020
02 12 2020
Historique:
received:
15
09
2020
revised:
17
11
2020
accepted:
24
11
2020
entrez:
5
12
2020
pubmed:
6
12
2020
medline:
24
6
2021
Statut:
epublish
Résumé
The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlying the alteration of synaptic function in PD, a proteomic study was performed. Therefore, synaptosomes were isolated by density gradient centrifugation from SNpc tissue of individuals at advanced PD stages (N = 5) as well as control subjects free of pathology (N = 5) followed by mass spectrometry-based analysis. In total, 362 proteins were identified and assigned to the synaptosomal core proteome. This core proteome comprised all proteins expressed within the synapses without regard to data analysis software, gender, age, or disease. The differential analysis between control subjects and PD cases revealed that CD9 antigen was overrepresented and fourteen proteins, among them Thymidine kinase 2 (TK2), mitochondrial, 39S ribosomal protein L37, neurolysin, and Methionine-tRNA ligase (MARS2) were underrepresented in PD suggesting an alteration in mitochondrial translation within synaptosomes.
Identifiants
pubmed: 33276480
pii: cells9122580
doi: 10.3390/cells9122580
pmc: PMC7761546
pii:
doi:
Substances chimiques
Melanins
0
Proteome
0
neuromelanin
0
thymidine kinase 2
EC 2.7.1.-
Thymidine Kinase
EC 2.7.1.21
Metalloendopeptidases
EC 3.4.24.-
neurolysin
EC 3.4.24.16
Methionine-tRNA Ligase
EC 6.1.1.10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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