Tumor-Infiltrating Natural Killer Cells.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
15
05
2020
revised:
03
08
2020
accepted:
14
08
2020
pubmed:
6
12
2020
medline:
25
11
2021
entrez:
5
12
2020
Statut:
ppublish
Résumé
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional. SIGNIFICANCE: The functions of tumor-infiltrating NK cells may be impaired. This review aims to describe the various mechanisms by which tumors alter NK-cell functions.
Identifiants
pubmed: 33277307
pii: 2159-8290.CD-20-0655
doi: 10.1158/2159-8290.CD-20-0655
pmc: PMC7611243
mid: EMS128589
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-44Subventions
Organisme : European Research Council
ID : 694502
Pays : International
Organisme : European Research Council
ID : 875102
Pays : International
Informations de copyright
©2020 American Association for Cancer Research.
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