Baseline Oral Microbiome and All-cancer Incidence in a Cohort of Nonsmoking Mexican American Women.
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
31
07
2020
revised:
12
10
2020
accepted:
18
11
2020
pubmed:
6
12
2020
medline:
3
3
2022
entrez:
5
12
2020
Statut:
ppublish
Résumé
Given the increasing evidence that the oral microbiome is involved in obesity, diabetes, and cancer risk, we investigated baseline oral microbiota profiles in relation to all-cancer incidence among nonsmoking women enrolled in a Texas cohort of first- and second-generation immigrants of Mexican origin. We characterized the 16Sv4 rDNA microbiome in oral mouthwash samples collected at baseline from a representative subset of 305 nonsmoking women, ages 20-75 years. We evaluated within- (alpha) and between-sample (beta) diversity by incident cancer status and applied linear discriminant analysis (LDA) effect size analysis to assess differentially abundant taxa. Diversity and candidate taxa in relation to all-cancer incidence were evaluated in multivariable-adjusted Cox regression models. Over 8.8 median years of follow-up, 31 incident cancer cases were identified and verified. Advanced age, greater acculturation, and cardiometabolic risk factors were associated with all-cancer incidence. Higher alpha diversity (age-adjusted
Identifiants
pubmed: 33277317
pii: 1940-6207.CAPR-20-0405
doi: 10.1158/1940-6207.CAPR-20-0405
pmc: PMC8137515
mid: NIHMS1649967
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
383-392Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA057730
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
Nat Rev Microbiol. 2019 Mar;17(3):156-166
pubmed: 30546113
J Intern Med. 2016 Jul;280(1):114-28
pubmed: 26791914
Theranostics. 2017 Sep 26;7(17):4313-4321
pubmed: 29158828
Front Microbiol. 2017 Nov 15;8:2244
pubmed: 29187843
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4516-22
pubmed: 20534432
mSphere. 2016 May 11;1(3):
pubmed: 27303740
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Cell Host Microbe. 2011 Oct 20;10(4):324-35
pubmed: 22018233
Lancet Microbe. 2020 Jul;1(3):e105
pubmed: 32835339
Oncotarget. 2017 Dec 16;9(19):15090-15100
pubmed: 29599929
Front Cell Infect Microbiol. 2017 Jun 30;7:295
pubmed: 28713780
Front Microbiol. 2018 Apr 20;9:774
pubmed: 29731748
Gut. 2012 Apr;61(4):582-8
pubmed: 21994333
Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1255-1265
pubmed: 28765338
CA Cancer J Clin. 2018 Nov;68(6):425-445
pubmed: 30285281
mSystems. 2019 Nov 26;4(6):
pubmed: 31771977
Sci Rep. 2020 Feb 7;10(1):2133
pubmed: 32034250
Int J Cancer. 2019 May 15;144(10):2381-2389
pubmed: 30365870
Cancer Res. 2017 Dec 1;77(23):6777-6787
pubmed: 29196415
J Dent Res. 2020 Dec;99(13):1411-1424
pubmed: 32811287
J Oral Microbiol. 2019 Aug 9;11(1):1650597
pubmed: 31489128
Front Cell Infect Microbiol. 2014 Jun 26;4:85
pubmed: 25019064
Gut. 2018 Jan;67(1):120-127
pubmed: 27742762
Nat Methods. 2013 Oct;10(10):996-8
pubmed: 23955772
Am J Public Health. 2016 Mar;106(3):547-9
pubmed: 26794174
Cell Host Microbe. 2017 Sep 13;22(3):269-278.e3
pubmed: 28910633
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Genome Biol. 2019 Nov 1;20(1):219
pubmed: 31672155
World J Gastroenterol. 2014 Jan 28;20(4):908-22
pubmed: 24574765
PLoS One. 2015 Dec 07;10(12):e0143603
pubmed: 26641451
Clin Oral Implants Res. 2014 Oct;25(10):1192-9
pubmed: 23845046
Cancer Med. 2020 Sep;9(17):6306-6321
pubmed: 32638533
Microbiome. 2015 Mar 06;3:7
pubmed: 25763184
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
PLoS One. 2018 Apr 25;13(4):e0194100
pubmed: 29694348
Sci Rep. 2017 Sep 18;7(1):11773
pubmed: 28924229
J Bacteriol. 2010 Oct;192(19):5002-17
pubmed: 20656903
BMC Microbiol. 2009 Dec 15;9:259
pubmed: 20003481
Int J Epidemiol. 2017 Apr 1;46(2):e3
pubmed: 25747868
Front Cell Infect Microbiol. 2018 Jul 24;8:243
pubmed: 30087857
Appl Environ Microbiol. 2007 Mar;73(5):1576-85
pubmed: 17220268
Front Cell Infect Microbiol. 2017 Dec 15;7:516
pubmed: 29326886
Infect Dis Clin North Am. 2007 Jun;21(2):471-502, vii
pubmed: 17561079
Gut. 2018 Aug;67(8):1454-1463
pubmed: 28988196
Gut. 2019 Jul;68(7):1335-1337
pubmed: 29934439
Oncotarget. 2017 Aug 14;8(50):88122-88138
pubmed: 29152146