Additive Effects of Arsenic and Aristolochic Acid in Chemical Carcinogenesis of Upper Urinary Tract Urothelium.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
21
07
2020
revised:
21
09
2020
accepted:
01
12
2020
pubmed:
6
12
2020
medline:
4
1
2022
entrez:
5
12
2020
Statut:
ppublish
Résumé
Aristolochic acids (AA) and arsenic are chemical carcinogens associated with urothelial carcinogenesis. Here we investigate the combined effects of AA and arsenic toward the risk of developing upper tract urothelial carcinoma (UTUC). Hospital-based ( In the hospital cohort, 43, 26, and 20 patients resided in grade 0, 1+2, and 3 arseniasis-endemic areas, respectively. Aristolactam-DNA adducts were present in >90% of these patients, indicating widespread AA exposure. A>T mutations in Exposure to both AA and arsenic acts additively to increase the UTUC risk in Taiwan. This is the first study to investigate the combined effect of AA and arsenic exposure on UTUC.
Sections du résumé
BACKGROUND
Aristolochic acids (AA) and arsenic are chemical carcinogens associated with urothelial carcinogenesis. Here we investigate the combined effects of AA and arsenic toward the risk of developing upper tract urothelial carcinoma (UTUC).
METHODS
Hospital-based (
RESULTS
In the hospital cohort, 43, 26, and 20 patients resided in grade 0, 1+2, and 3 arseniasis-endemic areas, respectively. Aristolactam-DNA adducts were present in >90% of these patients, indicating widespread AA exposure. A>T mutations in
CONCLUSIONS
Exposure to both AA and arsenic acts additively to increase the UTUC risk in Taiwan.
IMPACT
This is the first study to investigate the combined effect of AA and arsenic exposure on UTUC.
Identifiants
pubmed: 33277322
pii: 1055-9965.EPI-20-1090
doi: 10.1158/1055-9965.EPI-20-1090
pmc: PMC8083126
mid: NIHMS1653482
doi:
Substances chimiques
Aristolochic Acids
0
DNA Adducts
0
Arsenic
N712M78A8G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
317-325Subventions
Organisme : NCI NIH HHS
ID : P30 CA077598
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220367
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019564
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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