Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 12 2020
04 12 2020
Historique:
received:
08
07
2020
accepted:
17
11
2020
entrez:
5
12
2020
pubmed:
6
12
2020
medline:
18
12
2020
Statut:
epublish
Résumé
The aim of this study was to evaluate the impact of early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis on patients admitted to the San Raffaele Hospital (Milan, Italy) with moderate/severe COVID-19 and availability of at least two nasopharyngeal swabs. The primary outcome was the time to nasopharyngeal swab negativization. A multivariable Cox model was fitted to determine factors associated with nasopharyngeal swab negativization. Of 280 patients included, 59 (21.1%) patients were treated with steroids. Differences observed between steroid users and non-users included the proportion of patients with a baseline PaO
Identifiants
pubmed: 33277573
doi: 10.1038/s41598-020-78039-1
pii: 10.1038/s41598-020-78039-1
pmc: PMC7718220
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21291Investigateurs
A Andolina
(A)
M Baiardo Redaelli
(MB)
E Baldissera
(E)
G Bigai
(G)
A Bigoloni
(A)
N Boffini
(N)
G Borio
(G)
S Bossolasco
(S)
E Bruzzesi
(E)
M G Calabrò
(MG)
S Calvisi
(S)
C Campochiaro
(C)
D Canetti
(D)
V Canti
(V)
J Castellani
(J)
B Castiglioni
(B)
G Cavalli
(G)
L Cavallo
(L)
M Cernuschi
(M)
M Chiurlo
(M)
M Cilla
(M)
E Cinel
(E)
P Cinque
(P)
C Conte
(C)
V Da Prat
(V)
A Danise
(A)
R De Lorenzo
(R)
G De Luca
(G)
A Dell'Acqua
(A)
R Dell'Acqua
(R)
E Della-Torre
(E)
L Della Torre
(LD)
G Di Terlizzi
(G)
I Dumea
(I)
F Farolfi
(F)
M Ferrante
(M)
C Frangi
(C)
L Fumagalli
(L)
G Gallina
(G)
B Germinario
(B)
N Gianotti
(N)
H Hasson
(H)
F Lalla
(F)
G Landoni
(G)
M Lanzillotta
(M)
R Li Voti
(RL)
A Mastrangelo
(A)
E Messina
(E)
E Moizo
(E)
M Montagna
(M)
G Monti
(G)
G Morsica
(G)
C Muccini
(C)
S Nozza
(S)
C Oltolini
(C)
M Pascali
(M)
A Patrizi
(A)
M Pieri
(M)
D Prestifilippo
(D)
G Ramirez
(G)
M Ranzenigo
(M)
J Sapienza
(J)
S Sartorelli
(S)
F Seghi
(F)
G Tambussi
(G)
C Tassan Din
(CT)
A Tomelleri
(A)
S Turi
(S)
C Uberti-Foppa
(C)
C Vinci
(C)
Commentaires et corrections
Type : ErratumIn
Références
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Lancet. 2020 Feb 29;395(10225):683-684
pubmed: 32122468
Biomed Pharmacother. 2020 Aug;128:110267
pubmed: 32410772
JAMA. 2020 Oct 6;324(13):1307-1316
pubmed: 32876695
Expert Rev Vaccines. 2008 May;7(4):467-79
pubmed: 18444893
Clin Infect Dis. 2020 Nov 19;71(16):2114-2120
pubmed: 32427279
JAMA. 2020 Oct 6;324(13):1298-1306
pubmed: 32876689
J Heart Lung Transplant. 2020 May;39(5):405-407
pubmed: 32362390
BMJ. 2020 Apr 21;369:m1443
pubmed: 32317267
Leukemia. 2020 Jun;34(6):1503-1511
pubmed: 32372026
Med J Aust. 2020 May;212(9):416-420
pubmed: 32266987
JAMA. 2020 Oct 6;324(13):1317-1329
pubmed: 32876697
JAMA. 2020 Oct 6;324(13):1330-1341
pubmed: 32876694
J Infect. 2020 Jul;81(1):147-178
pubmed: 32283153
Ann Am Thorac Soc. 2020 Jul;17(7):879-891
pubmed: 32267771
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264