Environmental sensing and regulation of motility in Toxoplasma.
Toxoplasma
Apicomplexa
Ca2+
cAMP
cGMP
environmental sensing
gliding motility
signal transduction
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
27
11
2020
received:
21
09
2020
accepted:
01
12
2020
pubmed:
6
12
2020
medline:
1
12
2021
entrez:
5
12
2020
Statut:
ppublish
Résumé
Toxoplasma and other apicomplexan parasites undergo a unique form of cellular locomotion referred to as "gliding motility." Gliding motility is crucial for parasite survival as it powers tissue dissemination, host cell invasion and egress. Distinct environmental cues lead to activation of gliding motility and have become a prominent focus of recent investigation. Progress has been made toward understanding what environmental cues are sensed and how these signals are transduced in order to regulate the machinery and cellular events powering gliding motility. In this review, we will discuss new findings and integrate these into our current understanding to propose a model of how environmental sensing is achieved to regulate gliding motility in Toxoplasma. Collectively, these findings also have implications for the understanding of gliding motility across Apicomplexa more broadly.
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
916-929Informations de copyright
© 2020 John Wiley & Sons Ltd.
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