Role of rheology in tears and artificial tears.
Journal
Journal of cataract and refractive surgery
ISSN: 1873-4502
Titre abrégé: J Cataract Refract Surg
Pays: United States
ID NLM: 8604171
Informations de publication
Date de publication:
01 May 2021
01 May 2021
Historique:
received:
30
07
2020
accepted:
24
09
2020
pubmed:
6
12
2020
medline:
29
7
2021
entrez:
5
12
2020
Statut:
ppublish
Résumé
The study of viscoelastic fluids as artificial tears dates back to the late 1970s. Healon, the first ophthalmic viscosurgical device, was approved in 1980, but studied extensively before then, exhibits very interesting shear-thinning properties that were found to be beneficial in both ophthalmic surgery and somewhat later as a tear replacement solution. Unlike the previous tear film replacements, which were mainly viscous in nature, viscoelastic solutions, particularly those based on hyaluronan, exhibited very interesting, potentially beneficial, rheological properties, especially when slightly altered to become elastoviscous. This review examines the rheological properties that are significant in artificial tear solutions. We define herein the necessary parameters that need to be further studied to design and formulate rheologically better artificial tears, which should provide enhanced efficacy compared with their predecessors.
Identifiants
pubmed: 33278231
pii: 02158034-202105000-00017
doi: 10.1097/j.jcrs.0000000000000508
doi:
Substances chimiques
Lubricant Eye Drops
0
Ophthalmic Solutions
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
655-661Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of ASCRS and ESCRS.
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