Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort.

Air Pollutants / analysis Air Pollution / adverse effects Environmental Exposure / analysis Europe / epidemiology Humans Incidence Lung Neoplasms / chemically induced Particulate Matter / analysis
Air pollution Elemental components Fine particulate matter Lung cancer incidence Pooled cohort

Journal

Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621

Informations de publication

Date de publication:
02 2021
Historique:
received: 21 10 2020
revised: 20 11 2020
accepted: 29 11 2020
pubmed: 6 12 2020
medline: 20 4 2021
entrez: 5 12 2020
Statut: ppublish

Résumé

An association between long-term exposure to fine particulate matter (PM We pooled seven cohorts from across Europe and assigned exposure estimates for eight components of PM The pooled study population comprised 306,550 individuals with 3916 incident lung cancer events during 5,541,672 person-years of follow-up. We observed a positive association between exposure to all eight components and lung cancer incidence, with adjusted HRs of 1.10 (95% CI 1.05, 1.16) per 50 ng/m Our results point towards an increased risk of lung cancer in connection with sources of combustion particles from oil and biomass burning and secondary inorganic aerosols rather than non-exhaust traffic emissions. Specific limit values or guidelines targeting these specific PM

Sections du résumé

BACKGROUND
An association between long-term exposure to fine particulate matter (PM
METHODS
We pooled seven cohorts from across Europe and assigned exposure estimates for eight components of PM
RESULTS
The pooled study population comprised 306,550 individuals with 3916 incident lung cancer events during 5,541,672 person-years of follow-up. We observed a positive association between exposure to all eight components and lung cancer incidence, with adjusted HRs of 1.10 (95% CI 1.05, 1.16) per 50 ng/m
CONCLUSIONS
Our results point towards an increased risk of lung cancer in connection with sources of combustion particles from oil and biomass burning and secondary inorganic aerosols rather than non-exhaust traffic emissions. Specific limit values or guidelines targeting these specific PM

Identifiants

DOI: 10.1016/j.envres.2020.110568 PMID: 33278469
pubmed: 33278469
pii: S0013-9351(20)31465-1
doi: 10.1016/j.envres.2020.110568
pii:
doi:

Substances chimiques

Air Pollutants 0
Particulate Matter 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

110568

Subventions

Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Ulla Arthur Hvidtfeldt (UA)

Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, 2100, Denmark. Electronic address: ullah@cancer.dk.

Jie Chen (J)

Institute of Risk Assessment Sciences, University of Utrecht, P.O. Box 80177, Utrecht, NL 3508 TD, the Netherlands. Electronic address: j.chen1@uu.nl.

Zorana Jovanovic Andersen (ZJ)

Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, 1014, Denmark. Electronic address: zorana.andersen@sund.ku.dk.

Richard Atkinson (R)

Population Health Research Institute and MRC-PHE Centre for Environment and Health, St George's, University of London, London, UK. Electronic address: atkinson@sgul.ac.uk.

Mariska Bauwelinck (M)

Interface Demography - Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, 1050, Belgium. Electronic address: mariska.bauwelinck@vub.ac.be.

Tom Bellander (T)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Solnavägen 4, Plan 10, Stockholm, SE-113 65, Sweden. Electronic address: tom.bellander@ki.se.

Jørgen Brandt (J)

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, Roskilde, 4000, Denmark; IClimate - Aarhus University Interdisciplinary Centre for Climate Change, Frederiksborgvej 399, P.O.Box 358, Roskilde, 4000, Denmark. Electronic address: jbr@envs.au.dk.

Bert Brunekreef (B)

Institute of Risk Assessment Sciences, University of Utrecht, P.O. Box 80177, Utrecht, NL 3508 TD, the Netherlands. Electronic address: B.Brunekreef@uu.nl.

Giulia Cesaroni (G)

Department of Epidemiology, Lazio Region Health Service / ASL Roma 1, Via Cristoforo Colombo 112, Rome, 00147, Italy. Electronic address: g.cesaroni@deplazio.it.

Hans Concin (H)

Agency for Preventive and Social Medicine, Rheinstraße 61, Bregenz, 6900, Austria. Electronic address: Hans.Concin@aks.or.at.

Daniela Fecht (D)

UK Small Area Health Statistics Unit, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK. Electronic address: d.fecht@imperial.ac.uk.

Francesco Forastiere (F)

Institute for Biomedical Research and Innovation (IRIB), National Research Council, Palermo, 90146, Italy; Environmental Research Group, Imperial College, London, W12 0BZ, UK. Electronic address: fran.forastiere@gmail.com.

Carla H van Gils (CH)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, GA, Utrecht, 3508, the Netherlands. Electronic address: C.vanGils@umcutrecht.nl.

John Gulliver (J)

Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, LE1 7RH, UK. Electronic address: jg435@leicester.ac.uk.

Ole Hertel (O)

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, Roskilde, 4000, Denmark. Electronic address: oh@envs.au.dk.

Gerard Hoek (G)

Institute of Risk Assessment Sciences, University of Utrecht, P.O. Box 80177, Utrecht, NL 3508 TD, the Netherlands. Electronic address: G.Hoek@uu.nl.

Barbara Hoffmann (B)

Institute of Occupational, Social and Environmental Medicine, Medical Faculty, Heinrich Heine University, Gurlittstraße 55, Dusseldorf, 40223, Germany. Electronic address: b.hoffmann@uni-duesseldorf.de.

Kees de Hoogh (K)

Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel, 4051, Switzerland; University of Basel, Petersplatz 1, Postfach, Basel, 4001, Switzerland. Electronic address: c.dehoogh@swisstph.ch.

Nicole Janssen (N)

National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: nicole.janssen@rivm.nl.

Jeanette Therming Jørgensen (JT)

Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, 1014, Denmark. Electronic address: jethe@sund.ku.dk.

Klea Katsouyanni (K)

Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School 75, Mikras Asias Street, Athens, 115 27, Greece; NIHR HPRU Health Impact of Environmental Hazards, School of Public Health, Imperial College, London, UK. Electronic address: kkatsouy@med.uoa.gr.

Karl-Heinz Jöckel (KH)

Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, 45147, Germany. Electronic address: k-h.Joeckel@uk-essen.de.

Matthias Ketzel (M)

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, Roskilde, 4000, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, United Kingdom. Electronic address: mke@envs.au.dk.

Jochem O Klompmaker (JO)

Institute of Risk Assessment Sciences, University of Utrecht, P.O. Box 80177, Utrecht, NL 3508 TD, the Netherlands; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, 45147, Germany. Electronic address: jochem.klompmaker@rivm.nl.

Alois Lang (A)

Cancer Registry Vorarlberg, Agency for Preventive and Social Medicine, Rheinstraße 61, Bregenz, 6900, Austria. Electronic address: alois.lang@vol.at.

Karin Leander (K)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden. Electronic address: karin.leander@ki.se.

Shuo Liu (S)

Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, 1014, Denmark. Electronic address: shli@sund.ku.dk.

Petter L S Ljungman (PLS)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden; Department of Cardiology, Danderyd University Hospital, Stockholm, Sweden. Electronic address: petter.ljungman@ki.se.

Patrik K E Magnusson (PKE)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden. Electronic address: patrik.magnusson@ki.se.

Amar Jayant Mehta (AJ)

Statistics Denmark, Sejrøgade 11, 2100, Copenhagen, Denmark; Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, 1014, Copenhagen, Denmark. Electronic address: amar.mehta@sund.ku.dk.

Gabriele Nagel (G)

Agency for Preventive and Social Medicine, Rheinstraße 61, Bregenz, 6900, Austria; Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081, Ulm, Germany. Electronic address: gabriele.nagel@uni-ulm.de.

Bente Oftedal (B)

Section of Air Pollution and Noise, Norwegian Institute of Public Health, P.O. Box 222, Skøyen, N-0213, Oslo, Norway. Electronic address: bente.oftedal@fhi.no.

Göran Pershagen (G)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Solnavägen 4, Plan 10, Stockholm, SE-113 65, Sweden. Electronic address: goran.pershagen@ki.se.

Raphael Simon Peter (RS)

Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081, Ulm, Germany. Electronic address: Raphael.Peter@uni-ulm.de.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany; Chair of Epidemiology, Ludwig Maximilians Universität München, Munich, Germany. Electronic address: peters@helmholtz-muenchen.de.

Matteo Renzi (M)

Department of Epidemiology, Lazio Region Health Service / ASL Roma 1, Via Cristoforo Colombo 112, Rome, 00147, Italy. Electronic address: m.renzi@deplazio.it.

Debora Rizzuto (D)

Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, 17165, Sweden; Stockholm Gerontology Research Center, Stockholm, 11346, Sweden. Electronic address: debora.rizzuto@ki.se.

Sophia Rodopoulou (S)

Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School 75, Mikras Asias Street, Athens, 115 27, Greece. Electronic address: srodopoyl@med.uoa.gr.

Evangelia Samoli (E)

Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School 75, Mikras Asias Street, Athens, 115 27, Greece. Electronic address: esamoli@med.uoa.gr.

Per Everhard Schwarze (PE)

Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: per.schwarze@fhi.no.

Gianluca Severi (G)

CESP, UMR 1018, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications "G. Parenti" (DISIA), University of Florence, Italy. Electronic address: gianluca.severi@inserm.fr.

Torben Sigsgaard (T)

Department of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Bartholins Allé 2, 8000, Aarhus, Denmark. Electronic address: ts@ph.au.dk.

Massimo Stafoggia (M)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden; Department of Epidemiology, Lazio Region Health Service / ASL Roma 1, Via Cristoforo Colombo 112, Rome, 00147, Italy. Electronic address: m.stafoggia@deplazio.it.

Maciej Strak (M)

Institute of Risk Assessment Sciences, University of Utrecht, P.O. Box 80177, Utrecht, NL 3508 TD, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: maciek.strak@rivm.nl.

Danielle Vienneau (D)

University of Basel, Petersplatz 1, Postfach, Basel, 4001, Switzerland; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: danielle.vienneau@unibas.ch.

Gudrun Weinmayr (G)

Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081, Ulm, Germany. Electronic address: Gudrun.Weinmayr@uni-ulm.de.

Kathrin Wolf (K)

Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany. Electronic address: kathrin.wolf@helmholtz-muenchen.de.

Ole Raaschou-Nielsen (O)

Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, 2100, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, Roskilde, 4000, Denmark. Electronic address: ole@cancer.dk.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Régions géographiques › Europe › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Long-term exposure to fine particle elemental...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Long-term exposure to fine particle elemental...