Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation.
Journal
Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
06
10
2020
revised:
23
11
2020
accepted:
29
11
2020
pubmed:
6
12
2020
medline:
22
4
2021
entrez:
5
12
2020
Statut:
ppublish
Résumé
The bone marrow microenvironment contains cellular niches that maintain the pool of hematopoietic stem and progenitor cells and support hematopoietic maturation. Malignant hematopoietic cells also co-opt normal cellular interactions to promote their own growth and evade therapy. In vivo systems used to study human hematopoiesis have been developed through transplantation into immunodeficient mouse models. However, incomplete cross-compatibility between the murine stroma and transplanted human hematopoietic cells limits the rate of engraftment and the study of relevant interactions. To supplement in vivo xenotransplantation models, complementary strategies have recently been developed, including the use of three-dimensional human bone marrow organoids in vivo, generated from bone marrow stromal cells seeded onto osteo-inductive scaffolds, as well as the use of ex vivo bioreactor models. These topics were the focus of the Spring 2020 International Society for Experimental Hematology New Investigator webinar. We review here the latest advances in generating humanized hematopoietic organoids and how they allow for the study of novel microenvironmental interactions.
Identifiants
pubmed: 33278488
pii: S0301-472X(20)30633-0
doi: 10.1016/j.exphem.2020.11.008
pmc: PMC7879567
mid: NIHMS1668258
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-25Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL150218
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00016/18
Pays : United Kingdom
Informations de copyright
Copyright © 2020 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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