Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study.
Aged
Area Under Curve
Breath Tests
COVID-19
/ pathology
Critical Illness
Discriminant Analysis
Female
Humans
Least-Squares Analysis
Male
Metabolomics
/ methods
Middle Aged
Pilot Projects
Principal Component Analysis
Prospective Studies
ROC Curve
Respiration, Artificial
Respiratory Distress Syndrome
/ pathology
SARS-CoV-2
/ isolation & purification
Volatile Organic Compounds
/ analysis
Breath analysis
COVID-19
Intensive care
Mechanical ventilation
Metabolomics
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
14
09
2020
revised:
06
11
2020
accepted:
17
11
2020
pubmed:
7
12
2020
medline:
29
1
2021
entrez:
6
12
2020
Statut:
ppublish
Résumé
Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. In this prospective observational study, we used real-time, online, proton transfer reaction time-of-flight mass spectrometry to perform a metabolomic analysis of expired air from adults undergoing invasive mechanical ventilation in the intensive care unit due to severe COVID-19 or non-COVID-19 acute respiratory distress syndrome (ARDS). Between March 25 The real-time, non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify ARDS patients with COVID-19. The study was funded by Agence Nationale de la Recherche (SoftwAiR, ANR-18-CE45-0017 and RHU4 RECORDS, Programme d'Investissements d'Avenir, ANR-18-RHUS-0004), Région Île de France (SESAME 2016), and Fondation Foch.
Sections du résumé
BACKGROUND
BACKGROUND
Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19.
METHODS
METHODS
In this prospective observational study, we used real-time, online, proton transfer reaction time-of-flight mass spectrometry to perform a metabolomic analysis of expired air from adults undergoing invasive mechanical ventilation in the intensive care unit due to severe COVID-19 or non-COVID-19 acute respiratory distress syndrome (ARDS).
FINDINGS
RESULTS
Between March 25
INTERPRETATION
CONCLUSIONS
The real-time, non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify ARDS patients with COVID-19.
FUNDING
BACKGROUND
The study was funded by Agence Nationale de la Recherche (SoftwAiR, ANR-18-CE45-0017 and RHU4 RECORDS, Programme d'Investissements d'Avenir, ANR-18-RHUS-0004), Région Île de France (SESAME 2016), and Fondation Foch.
Identifiants
pubmed: 33279860
pii: S2352-3964(20)30530-2
doi: 10.1016/j.ebiom.2020.103154
pmc: PMC7714658
pii:
doi:
Substances chimiques
Volatile Organic Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103154Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
Références
J Breath Res. 2014 Mar;8(1):014001
pubmed: 24421258
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
Sci Rep. 2015 Nov 26;5:17179
pubmed: 26608483
Eur Respir J. 2014 May;43(5):1522-5
pubmed: 24789953
J Proteome Res. 2015 Aug 7;14(8):3322-35
pubmed: 26088811
Respir Med. 2018 Mar;136:111-117
pubmed: 29501241
J Breath Res. 2017 Jan 09;11(1):016005
pubmed: 28068288
Eur Respir J. 2014 Jul;44(1):188-97
pubmed: 24743964
J Breath Res. 2016 Jun 16;10(3):036001
pubmed: 27310311
Bioanalysis. 2013 Jun;5(11):1443-59
pubmed: 23742311
Sci Immunol. 2020 Jul 15;5(49):
pubmed: 32669287
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
Intensive Care Med. 1996 Jul;22(7):707-10
pubmed: 8844239
JAMA. 1993 Dec 22-29;270(24):2957-63
pubmed: 8254858
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Eur Respir J. 2013 Jan;41(1):183-8
pubmed: 23277518
Intensive Care Med. 1998 May;24(5):415-21
pubmed: 9660254
Eur Respir J. 2004 Dec;24(6):1011-7
pubmed: 15572547
J Infect. 2017 Nov;75(5):441-447
pubmed: 28804027
Respir Med. 2015 Nov;109(11):1454-9
pubmed: 26440675
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
N Engl J Med. 2020 Sep 3;383(10):994
pubmed: 32649078
BMC Bioinformatics. 2009 Feb 19;10:62
pubmed: 19228411
J Breath Res. 2019 Jul 09;13(4):046004
pubmed: 31185457
Trends Biotechnol. 2014 Oct;32(10):538-48
pubmed: 25179940
J Biochem Mol Biol. 2003 Jan 31;36(1):95-109
pubmed: 12542980
Anal Chem. 2013 Nov 5;85(21):10321-9
pubmed: 24044609
J Breath Res. 2014 Sep;8(3):034001
pubmed: 24946087
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Sci Rep. 2018 Oct 5;8(1):14857
pubmed: 30291257
Clin Infect Dis. 2014 Dec 15;59(12):1733-40
pubmed: 25342502
Cell. 2020 Jul 9;182(1):59-72.e15
pubmed: 32492406
BMC Pulm Med. 2014 Apr 26;14:72
pubmed: 24767549
J Breath Res. 2015 Jan 05;9(1):016004
pubmed: 25557917