Robotic-assisted radiosurgery for the treatment of vasoproliferative tumours.
CyberKnife
benign intraocular tumour
reactive retinal astrocytic tumour
robotic radiosurgery
stereotactic radiosurgery
vasoproliferative tumour
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
20
07
2020
received:
16
01
2020
accepted:
11
08
2020
pubmed:
7
12
2020
medline:
25
11
2021
entrez:
6
12
2020
Statut:
ppublish
Résumé
Vasoproliferative tumours (VPT) are a rare but benign entity that can lead to severe visual acuity deterioration. There is no standard of care, and depending on the degree of clinical features, including tumour size and dissemination, visual acuity and subretinal fluid, treatment options include observation, cryotherapy and brachytherapy. Particularly in larger tumours, brachytherapy has advantages over other options, although higher radiation doses and the need for surgical application are disadvantages of this otherwise effective treatment option. CyberKnife radiosurgery might represent an alternative therapeutic option as no surgical intervention is needed and radiation doses are lower. All patients diagnosed with vasoproliferative tumors who were treated with CyberKnife radiosurgery with a minimum follow-up time of 12 months were included in this case series. We recorded visual acuity, number of lesions, central retinal thickness with optical coherence tomography (OCT) and reflectivity using A-scan standardizes echography every three months. A total of four patients with a median age of 34 years (range: 24 - 51) who were observed over an average of 26.5 months (range: 17 - 49 months) matched our inclusion criteria. We appreciated stabilization or increase in visual acuity in all four patients and a regression in tumour thickness with subsequent increase in internal reflectivity as a marker of increasing fibrosis. We observed good visual and functional outcome following CyberKnife therapy for VPT. We believe that further studies should be pursued to evaluate CyberKnife therapy for the treatment of VPT not treatable with cryo- or lasertherapy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
456-460Informations de copyright
© 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
Références
Anastassiou G, Bornfeld N, Schueler AO et al. (2006): Ruthenium-106 plaque brachytherapy for symptomatic vasoproliferative tumours of the retina. Br J Ophthalmol 90: 447-450.
Eibl-Lindner K, Furweger C, Nentwich M, Foerster P, Wowra B, Schaller U & Muacevic A (2016): Robotic radiosurgery for the treatment of medium and large uveal melanoma. Melanoma Res 26: 51-57.
Fernandez-Martinez C, Martinez-Toldos JJ & Hernandez-Artola F (2015): Laser and ranibizumab combination for retinal vasoproliferative tumor's management. Arch Soc Esp Oftalmol 90: 593-596.
Foulds WS, Damato BE & Burton RL (1987): Local resection versus enucleation in the management of choroidal melanoma. Eye (London, England) 1(Pt 6): 676-679.
Grossniklaus HE, Lenis TL & Jakobiec FA (2017): Retinal reactive astrocytic tumor (Focal Nodular Gliosis): the entity also known as vasoproliferative tumor. Ocul Oncol Pathol 3: 161-163.
Heimann H, Bornfeld N, Vij O, Coupland SE, Bechrakis NE, Kellner U & Foerster MH (2000): Vasoproliferative tumours of the retina. Br J Ophthalmol 84: 1162-1169.
Heimann H, Jmor F & Damato B (2013): Imaging of retinal and choroidal vascular tumours. Eye (London, England) 27: 208-216.
Henkind P & Morgan G (1966): Peripheral retinal angioma with exudative retinopathy in adults (coats's lesion). Br J Ophthalmol 50: 2-11.
Hussain RN, Jmor F, Damato B & Heimann H (2015): Verteporfin photodynamic therapy for the treatment of retinal vasoproliferative tumors. Ophthalmology 122: 2361-2363.
Irvine F, O'Donnell N, Kemp E & Lee WR (2000): Retinal vasoproliferative tumors: surgical management and histological findings. Arch Ophthalmol (Chicago, Ill. : 1960) 118: 563-569.
Kreusel KM, Bornfeld N, Lommatzsch A, Wessing A & Foerster MH (1998): Ruthenium-106 brachytherapy for peripheral retinal capillary hemangioma. Ophthalmology 105: 1386-1392.
Krivosic V, Massin P, Desjardins L, Le Hoang P, Tadayoni R & Gaudric A (2014): Management of idiopathic retinal vasoproliferative tumors by slit-lamp laser or endolaser photocoagulation. Am J Ophthalmol 158: 154-161.e151.
Laqua H & Wessing A (1983): Peripheral retinal telangiectasis in adults simulating a vascular tumor or melanoma. Ophthalmology 90: 1284-1291.
Liegl R, Schmelter V, Fuerweger C, Foerster MH, Muacevic A, Priglinger SG, Schaller UC & Foerster P (2020). Robotic cyberknife radiosurgery for ciliary body melanoma. Ophthalmol Retina 20. S2468-6530(20)30152-4. (online ahead of print). https://doi.org/10.1016/j.oret.2020.03.031
Madreperla SA, Hungerford JL, Plowman PN, Laganowski HC & Gregory PT (1997): Choroidal hemangiomas: visual and anatomic results of treatment by photocoagulation or radiation therapy. Ophthalmology 104: 1773-1778. discussion 1779.
Muacevic A, Nentwich M, Wowra B, Staerk S, Kampik A & Schaller U (2008): Development of a streamlined, non-invasive robotic radiosurgery method for treatment of uveal melanoma. Technol Cancer Res Treat 7: 369-374.
Para Prieto M, Saornil MA, de Frutos Baraja JM, Garcia Alvarez C, Diezhandino Garcia P & Lopez Lara F (2018): Episcleral brachytherapy as an effective alternative in vasoproliferative tumors. Int J Ophthalmol 11: 2017-2020.
Shields CL, Shields JA, Barrett J & De Potter P (1995): Vasoproliferative tumors of the ocular fundus. Classification and clinical manifestations in 103 patients. Arch Ophthalmol (Chicago, Ill. : 1960) 113: 615-623.
Temblador-Barba I, Delgado-Alonso EM, Toribio-Garcia M, Martinez-Campillo L, Molina-Leyva I & Martinez-Jimenez M (2018): Update on the management of vasoproliferative tumour. Arch Soc Esp Oftalmol 93: 350-353.
Walinjkar JA, Sharma US, Rishi P, Rishi E, Gopal L & Sharma T (2018): Clinical features and treatment outcomes of vasoproliferative tumors in Indian participants. Indian J Ophthalmol 66: 246-251.
Zheng B, Chen Y, Chen L et al. (2019): Comparative study on the efficacy and safety of tumor resection in vitrectomy for retinal vasoproliferative tumors. J Ophthalmol 2019: 7464123.