Cerebral Blood Flow and Cognitive Performance in Postural Tachycardia Syndrome: Insights from Sustained Cognitive Stress Test.
Adolescent
Adult
Blood Pressure
/ physiology
Carbon Dioxide
/ physiology
Case-Control Studies
Cerebrovascular Circulation
/ physiology
Cognitive Dysfunction
/ physiopathology
Female
Heart Rate
/ physiology
Hemodynamics
/ physiology
Humans
Male
Middle Cerebral Artery
/ diagnostic imaging
Neuropsychological Tests
/ standards
Orthostatic Intolerance
/ physiopathology
Postural Orthostatic Tachycardia Syndrome
/ physiopathology
Severity of Illness Index
Ultrasonography, Doppler, Transcranial
/ methods
Young Adult
cerebral blood flow
cognitive dysfunction
orthostatic intolerance
postural tachycardia syndrome
transcranial doppler
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
pubmed:
8
12
2020
medline:
16
3
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
Background The physiology underlying "brain fog" in the absence of orthostatic stress in postural tachycardia syndrome (POTS) remains poorly understood. Methods and Results We evaluated cognitive and hemodynamic responses (cardiovascular and cerebral: heart rate, blood pressure, end-tidal carbon dioxide, and cerebral blood flow velocity (CBFv) in the middle cerebral artery at baseline, after initial cognitive testing, and after (30-minutes duration) prolonged cognitive stress test (PCST) whilst seated; as well as after 5-minute standing in consecutively enrolled participants with POTS (n=22) and healthy controls (n=18). Symptom severity was quantified with orthostatic hypotensive questionnaire at baseline and end of study. Subjects in POTS and control groups were frequency age- and sex-matched (29±11 versus 28±13 years; 86 versus 72% women, respectively; both
Identifiants
pubmed: 33280488
doi: 10.1161/JAHA.120.017861
pmc: PMC7955388
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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