Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5).
Autophagy
blood-brain barrier
claudin 5
hypoxia
zebrafish
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
pubmed:
8
12
2020
medline:
8
4
2022
entrez:
7
12
2020
Statut:
ppublish
Résumé
Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB integrity remains unclear. Here we report that in BMECs of patients suffering stroke, CLDN5 (claudin 5) abnormally aggregates in the cytosol accompanied by autophagy activation.
Identifiants
pubmed: 33280500
doi: 10.1080/15548627.2020.1851897
pmc: PMC8526012
doi:
Substances chimiques
CLDN5 protein, human
0
Claudin-5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3048-3067Références
J Biol Chem. 2002 Mar 22;277(12):10201-8
pubmed: 11782481
Brain. 2004 Jun;127(Pt 6):1427-36
pubmed: 15130953
Methods. 2015 Mar;75:172-80
pubmed: 25498006
Autophagy. 2014 Oct 1;10(10):1844-57
pubmed: 25126731
Free Radic Res. 2009 Apr;43(4):348-64
pubmed: 19241241
J Biol Chem. 2014 Dec 26;289(52):35711-23
pubmed: 25371213
Acta Neuropathol. 2007 Nov;114(5):459-69
pubmed: 17687559
Nat Biotechnol. 2013 Mar;31(3):227-9
pubmed: 23360964
Brain Pathol. 2010 Mar;20(2):281-97
pubmed: 19725834
J Cell Biol. 2018 Oct 1;217(10):3354-3367
pubmed: 30143524
Front Physiol. 2019 Jan 18;10:2
pubmed: 30713499
Mol Cell Biol. 2009 May;29(10):2570-81
pubmed: 19273585
Mol Cell. 2004 Sep 10;15(5):767-76
pubmed: 15350220
PLoS One. 2012;7(12):e52627
pubmed: 23300727
Dev Cell. 2002 Aug;3(2):271-82
pubmed: 12194857
Cell. 2008 Jan 11;132(1):27-42
pubmed: 18191218
Zebrafish. 2017 Aug;14(4):322-330
pubmed: 28488933
Mol Neurobiol. 2016 Nov;53(9):5935-5947
pubmed: 26515186
EMBO J. 2013 Oct 16;32(20):2685-96
pubmed: 23974797
FEBS Lett. 2020 Apr;594(7):1155-1165
pubmed: 31823348
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1016-25
pubmed: 24727585
Trends Cell Biol. 2015 Jun;25(6):354-63
pubmed: 25759175
Nature. 2013 Sep 5;501(7465):45-51
pubmed: 24005412
Autophagy. 2016 Jun 2;12(6):1029-46
pubmed: 27166522
Prog Neurobiol. 2018 Apr - May;163-164:144-171
pubmed: 28987927
Sci Rep. 2016 Feb 08;6:20279
pubmed: 26854133
Cell Rep. 2015 Sep 22;12(11):1731-9
pubmed: 26344765
Autophagy. 2013 Nov 1;9(11):1693-709
pubmed: 23939015
Autophagy. 2014 Apr;10(4):572-87
pubmed: 24441423
Nat Rev Neurosci. 2006 Jan;7(1):41-53
pubmed: 16371949
Cell. 2001 Oct 5;107(1):43-54
pubmed: 11595184
Circ Res. 2015 Jan 30;116(3):468-79
pubmed: 25634970
J Physiol Pharmacol. 2011 Jun;62(3):287-93
pubmed: 21893688
Autophagy. 2009 Nov;5(8):1217-9
pubmed: 19829057
Nature. 2005 Jul 7;436(7047):128-33
pubmed: 16001074
Prog Neurobiol. 2018 Apr - May;163-164:79-97
pubmed: 28414101
Ann N Y Acad Sci. 2017 Jun;1397(1):54-65
pubmed: 28415156
J Biol Chem. 2009 Jul 10;284(28):19053-66
pubmed: 19423710
Cell Death Dis. 2018 Jul 10;9(7):771
pubmed: 29991726
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1425-30
pubmed: 20080584
Crit Care. 2009;13(1):R12
pubmed: 19196477
PLoS Genet. 2015 Feb 27;11(2):e1004987
pubmed: 25723488
Autophagy. 2010 Oct;6(7):958-60
pubmed: 20699640
EMBO Mol Med. 2015 Sep 28;7(11):1403-17
pubmed: 26417067
J Neurosci. 2012 Feb 29;32(9):3044-57
pubmed: 22378877
Blood. 2014 Jan 30;123(5):625-31
pubmed: 24300855
J Cereb Blood Flow Metab. 2013 Jan;33(1):37-47
pubmed: 22968321
Nat Commun. 2017 Jul 24;8(1):98
pubmed: 28740109
Autophagy. 2016 Oct 2;12(10):1864-1875
pubmed: 27467399
J Neurol Neurosurg Psychiatry. 2010 Feb;81(2):192-7
pubmed: 19710048
EMBO J. 2016 Jul 1;35(13):1368-84
pubmed: 27145933
Int J Biol Sci. 2019 Jun 2;15(7):1440-1451
pubmed: 31337974
FASEB J. 2007 Nov;21(13):3666-76
pubmed: 17586731
Autophagy. 2018;14(1):53-65
pubmed: 29130363
J Neurosci. 2012 Nov 7;32(45):15704-14
pubmed: 23136410
Neuroscience. 2016 Jul 7;327:53-63
pubmed: 27095710
Eur J Pharm Sci. 2001 Jan;12(3):215-22
pubmed: 11113640