Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study.
Aging
Cardiovascular
Multimorbidity
Musculoskeletal
Neuropsychiatric
Sleep disturbances
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
07 12 2020
07 12 2020
Historique:
received:
07
04
2020
accepted:
06
11
2020
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
16
3
2021
Statut:
epublish
Résumé
Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate-severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. Moderate-severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate-severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults.
Sections du résumé
BACKGROUND
Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults.
METHODS
Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate-severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome.
RESULTS
Moderate-severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate-severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded.
CONCLUSION
The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults.
Identifiants
pubmed: 33280611
doi: 10.1186/s12916-020-01846-w
pii: 10.1186/s12916-020-01846-w
pmc: PMC7720467
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
382Références
PLoS One. 2014 Dec 05;9(12):e114742
pubmed: 25478876
Eur J Public Health. 2013 Oct;23(5):799-804
pubmed: 23115329
J Clin Endocrinol Metab. 2005 May;90(5):3106-14
pubmed: 15728214
BMC Pulm Med. 2012 Sep 24;12:60
pubmed: 23006602
J Orthop Translat. 2017 Jul;10:52-67
pubmed: 28781962
Aging Clin Exp Res. 2004 Apr;16(2):158-68
pubmed: 15195992
Curr Hypertens Rep. 2018 Jul 10;20(9):79
pubmed: 29992504
J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):63-70
pubmed: 25104822
Sleep. 2019 Apr 1;42(4):
pubmed: 30649500
J Gerontol A Biol Sci Med Sci. 2020 May 22;75(6):1089-1094
pubmed: 31086967
Alzheimers Dement. 2018 Oct;14(10):1235-1242
pubmed: 30030112
Eur J Public Health. 2019 Feb 1;29(1):182-189
pubmed: 29878097
BMC Geriatr. 2015 Jan 05;15:1
pubmed: 25559550
BMJ. 2016 Nov 16;355:i5819
pubmed: 27852564
J Sleep Res. 2019 Aug;28(4):e12809
pubmed: 30609099
PLoS Med. 2018 Mar 6;15(3):e1002503
pubmed: 29509768
Sleep Breath. 2018 Sep;22(3):729-742
pubmed: 29248975
MMWR Morb Mortal Wkly Rep. 2016 Feb 19;65(6):137-41
pubmed: 26890214
J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1417-1423
pubmed: 28003375
Rand Health Q. 2017 Jan 1;6(4):11
pubmed: 28983434
Int J Mol Sci. 2017 Oct 16;18(10):
pubmed: 29035323
Clin Geriatr Med. 2014 Aug;30(3):591-627
pubmed: 25037297
Depress Anxiety. 2015 Sep;32(9):664-70
pubmed: 26047492
Sleep Med Rev. 2020 Oct;53:101332
pubmed: 32505969
Biol Psychiatry. 2016 Jul 1;80(1):40-52
pubmed: 26140821
Lancet Diabetes Endocrinol. 2015 Jan;3(1):52-62
pubmed: 24731536
Sleep Med Rev. 2012 Feb;16(1):83-94
pubmed: 21636297
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Glob Health Epidemiol Genom. 2018 Jun 4;3:e10
pubmed: 30263134
Sleep Med. 2018 Dec;52:26-33
pubmed: 30216820
Pathol Biol (Paris). 2014 Oct;62(5):276-83
pubmed: 25104243
Sleep Med. 2012 Feb;13(2):139-44
pubmed: 22137111
Physiol Rev. 2012 Jul;92(3):1087-187
pubmed: 22811426
Lancet Neurol. 2014 Oct;13(10):1017-28
pubmed: 25231524
Arthritis Care Res (Hoboken). 2020 Jul;72(7):991-1000
pubmed: 31207113
Ageing Res Rev. 2011 Sep;10(4):430-9
pubmed: 21402176
Am J Epidemiol. 2019 Sep 1;188(9):1627-1636
pubmed: 31274148
Sleep. 2017 May 1;40(5):
pubmed: 28329370
Acta Psychiatr Scand Suppl. 1978;(271):5-27
pubmed: 277059
Sleep. 2009 Sep;32(9):1221-8
pubmed: 19750927
Exp Gerontol. 2018 Feb;102:109-132
pubmed: 29237576
Sleep Med. 2017 May;33:151-159
pubmed: 28449896
Mayo Clin Proc. 2015 May;90(5):624-32
pubmed: 25863417
Gerontology. 2010;56(2):181-9
pubmed: 19738366
Sleep Med Rev. 2019 Dec;48:101208
pubmed: 31491656
J Sleep Res. 2014 Apr;23(2):143-52
pubmed: 24237855
Pain. 2014 Aug;155(8):1547-54
pubmed: 24793909
Psychoneuroendocrinology. 2014 Mar;41:46-62
pubmed: 24495607
Sleep. 2013 Oct 01;36(10):1533-41, 1541A
pubmed: 24082313
Lancet Neurol. 2019 Mar;18(3):307-318
pubmed: 30784558
Int Clin Psychopharmacol. 2004 Jan;19(1):1-7
pubmed: 15101563
Sleep Med. 2018 Dec;52:221-229
pubmed: 29861378
Front Neuroendocrinol. 2019 Jul;54:100746
pubmed: 31002895
J Clin Sleep Med. 2017 Apr 15;13(4):591-597
pubmed: 28212690
Curr Pain Headache Rep. 2009 Dec;13(6):447-54
pubmed: 19889286
J Am Med Dir Assoc. 2015 Aug 1;16(8):640-7
pubmed: 25958334
Sleep Med Rev. 2014 Jun;18(3):215-24
pubmed: 23835138
Sleep Med Rev. 2018 Jun;39:187-194
pubmed: 29126903
Sleep. 2011 Apr 01;34(4):443-50
pubmed: 21461322
J Clin Epidemiol. 2014 Mar;67(3):254-66
pubmed: 24472295
PLoS One. 2014 Jul 21;9(7):e102149
pubmed: 25048354
Sleep Med Clin. 2018 Mar;13(1):1-11
pubmed: 29412976
Sleep Med. 2017 Apr;32:246-256
pubmed: 27743803
J Am Coll Cardiol. 2018 May 15;71(19):2149-2161
pubmed: 29747836
Sleep Med Rev. 2018 Aug;40:4-16
pubmed: 28890168
Sleep Med Clin. 2017 Mar;12(1):31-38
pubmed: 28159095