Pleomorphic Invasive Lobular Carcinoma of the Breast With Extracellular Mucin and
HER2
Pleomorphic
breast
diagnosis
invasive
lobular
pathology
surgery
Journal
Breast cancer : basic and clinical research
ISSN: 1178-2234
Titre abrégé: Breast Cancer (Auckl)
Pays: United States
ID NLM: 101474356
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
10
2020
accepted:
30
10
2020
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
8
12
2020
Statut:
epublish
Résumé
Invasive lobular carcinoma with extracellular mucin is an uncommon pattern of invasive breast carcinoma. The 5th Edition of the World Health Organization Classification of Breast Tumors states that it is unknown whether these tumors are a subtype of mucinous carcinoma or invasive lobular carcinoma. Invasive lobular carcinoma with extracellular mucin frequently presents as a palpable mass and may be more likely to be grade 2 to 3 and HER2-positive than classic invasive lobular carcinoma. This case of pleomorphic invasive lobular carcinoma with extracellular mucin was detected by imaging only and was HER2-amplified, suggesting that a subset of these tumors may be clinically occult with an aggressive phenotype. Invasive lobular carcinoma with extracellular mucin is infrequently encountered and awareness of this entity is helpful in avoiding misdiagnosis.
Identifiants
pubmed: 33281451
doi: 10.1177/1178223420976383
pii: 10.1177_1178223420976383
pmc: PMC7691944
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1178223420976383Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of conflicting interests:The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: B.C.C. is a member of the Oncology Advisory Board for Luminex Corp. The other authors have no conflicts of interest or financial disclosures.
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