Mosaic Bovine Viral Diarrhea Virus Antigens Elicit Cross-Protective Immunity in Calves.
antigen cocktail
bovine viral diarrhea virus
cattle
cross-protection
efficacy
mosaic antigen
neutralizing antibody
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
07
2020
accepted:
14
10
2020
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
16
7
2021
Statut:
epublish
Résumé
Bovine Viral Diarrhea Virus (BVDV) is an important pathogen that plays a significant role in initiating Bovine Respiratory Disease Complex (BRDC) in cattle. The disease causes multi-billion dollar losses globally due to high calf mortality and increased morbidity leading to heavy use of antibiotics. Current commercial vaccines provide limited cross-protection with several drawbacks such as safety, immunosuppression, potential reversion to virulence, and induction of neonatal pancytopenia. This study evaluates two prototype vaccines containing multiple rationally designed recombinant mosaic BVDV antigens for their potential to confer cross-protection against diverse BVDV strains. Genes encoding three novel mosaic antigens, designated E2
Identifiants
pubmed: 33281819
doi: 10.3389/fimmu.2020.589537
pmc: PMC7690067
doi:
Substances chimiques
Antigens, Viral
0
Epitopes
0
Viral Vaccines
0
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
589537Informations de copyright
Copyright © 2020 Sangewar, Hassan, Lokhandwala, Bray, Reith, Markland, Sang, Yao, Fritz, Waghela, Abdelsalam, Chase and Mwangi.
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