Evolution and rapid spread of a reassortant A(H3N2) virus that predominated the 2017-2018 influenza season.

adaptation influenza phylogenetics reassortment

Journal

Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675

Informations de publication

Date de publication:
Jul 2019
Historique:
entrez: 7 12 2020
pubmed: 8 12 2020
medline: 8 12 2020
Statut: epublish

Résumé

The 2017-2018 North American influenza season caused more hospitalizations and deaths than any year since the 2009 H1N1 pandemic. The majority of recorded influenza infections were caused by A(H3N2) viruses, with most of the virus's North American diversity falling into the A2 clade. Within A2, we observe a subclade which we call A2/re that rose to comprise almost 70 per cent of A(H3N2) viruses circulating in North America by early 2018. Unlike most fast-growing clades, however, A2/re contains no amino acid substitutions in the hemagglutinin (HA) segment. Moreover, hemagglutination inhibition assays did not suggest substantial antigenic differences between A2/re viruses and viruses sampled during the 2016-2017 season. Rather, we observe that the A2/re clade was the result of a reassortment event that occurred in late 2016 or early 2017 and involved the combination of the HA and PB1 segments of an A2 virus with neuraminidase (NA) and other segments a virus from the clade A1b. The success of this clade shows the need for antigenic analysis that targets NA in addition to HA. Our results illustrate the potential for non-HA drivers of viral success and necessitate the need for more thorough tracking of full viral genomes to better understand the dynamics of influenza epidemics.

Identifiants

DOI: 10.1093/ve/vez046 PMID: 33282337 PMC: PMC6891002
pubmed: 33282337
doi: 10.1093/ve/vez046
pii: vez046
pmc: PMC6891002
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

vez046

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM119774
Pays : United States

Informations de copyright

Published by Oxford University Press 2019. This work is written by US Government employees and is in the public domain in the US.

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Auteurs

Barney I Potter (BI)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.
ORCID: 0000-0001-9476-149X

Rebecca Kondor (R)

Virology Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

James Hadfield (J)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.

John Huddleston (J)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.
Molecular and Cellular Biology Program, University of Washington, 4109 E Stevens Way NE, Seattle, WA 98105, USA.

John Barnes (J)

Virology Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

Thomas Rowe (T)

Virology Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

Lizheng Guo (L)

Virology Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

Xiyan Xu (X)

Virology Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

Richard A Neher (RA)

Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
SIB Swiss Institute of Bioinformatics, Klingelbergstrasse 70, 4056 Basel, Switzerland.
ORCID: 0000-0003-2525-1407

Trevor Bedford (T)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.

David E Wentworth (DE)

Virology Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

Classifications MeSH