Probe-hosted large area silicon photomultiplier and high-throughput timing electronics for enhanced performance time-domain functional near-infrared spectroscopy.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
23
06
2020
revised:
21
09
2020
accepted:
07
10
2020
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
8
12
2020
Statut:
epublish
Résumé
Two main bottlenecks prevent time-domain diffuse optics instruments to reach their maximum performances, namely the limited light harvesting capability of the detection chain and the bounded data throughput of the timing electronics. In this work, for the first time to our knowledge, we overcome both those limitations using a probe-hosted large area silicon photomultiplier detector coupled to high-throughput timing electronics. The system performances were assessed based on international protocols for diffuse optical imagers showing better figures with respect to a state-of-the-art device. As a first step towards applications, proof-of-principle in-vivo brain activation measurements demonstrated superior signal-to-noise ratio as compared to current technologies.
Identifiants
pubmed: 33282497
doi: 10.1364/BOE.400868
pii: 400868
pmc: PMC7687960
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6389-6412Informations de copyright
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
Sumeet Rohilla conducted his PhD at PicoQuant Innovations GmbH, financed by a joint European funding project (BitMap). Benedikt Krämer and Felix Koberling are employees of PicoQuant GmbH. PicoQuant produces time-resolved fluorescence microscopes and spectrometers, picosecond pulsed diode lasers as well as time correlated single photon counting equipment.
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