Effect of laser pulse shaping on photoacoustic dosimetry in retinal models.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
29
07
2020
revised:
14
10
2020
accepted:
15
10
2020
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
8
12
2020
Statut:
epublish
Résumé
Photoacoustic sensing can be a powerful technique to obtain real-time feedback of laser energy dose in treatments of biological tissue. However, when laser therapy uses pulses with microsecond duration, they are not optimal for photoacoustic pressure wave generation. This study examines a programmable fiber laser technique using pulse modulation in order to optimize the photoacoustic feedback signal to noise ratio (SNR) in a context where longer laser pulses are employed, such as in selective retinal therapy. We have demonstrated with a homogeneous tissue phantom that this method can yield a greater than seven-fold improvement in SNR over non-modulated square pulses of the same duration and pulse energy. This technique was further investigated for assessment of treatment outcomes in leporine retinal explants by photoacoustic mapping around the cavitation-induced frequency band.
Identifiants
pubmed: 33282510
doi: 10.1364/BOE.403703
pii: 403703
pmc: PMC7687941
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6590-6604Informations de copyright
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
Some authors have filed application for patent (US20180323571A1) and have a granted patent (US10390883B2). No authors have any financial benefit resulting from patents. Authors declare that there are no conflicts of interest related to this article.
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