Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.
Alzheimer's disease
LOAD
MRI
Open Science
PET
animal models
preclinical
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
10
2020
accepted:
09
10
2020
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
8
12
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved disease-modifying intervention. Both are essential to slow or stop the growth in dementia prevalence. While our current animal models of AD have provided novel insights into AD disease mechanisms, thus far, they have not been successfully used to predict the effectiveness of therapies that have moved into AD clinical trials. The Model Organism Development and Evaluation for Late-onset Alzheimer's Disease (MODEL-AD; www.model-ad.org) Consortium was established to maximize human datasets to identify putative variants, genes, and biomarkers for AD; to generate, characterize, and validate the next generation of mouse models of AD; and to develop a preclinical testing pipeline. MODEL-AD is a collaboration among Indiana University (IU); The Jackson Laboratory (JAX); University of Pittsburgh School of Medicine (Pitt); Sage BioNetworks (Sage); and the University of California, Irvine (UCI) that will generate new AD modeling processes and pipelines, data resources, research results, standardized protocols, and models that will be shared through JAX's and Sage's proven dissemination pipelines with the National Institute on Aging-supported AD Centers, academic and medical research centers, research institutions, and the pharmaceutical industry worldwide.
Identifiants
pubmed: 33283040
doi: 10.1002/trc2.12110
pii: TRC212110
pmc: PMC7683958
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12110Subventions
Organisme : NIA NIH HHS
ID : U54 AG054349
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
J Neurosci. 2014 Mar 12;34(11):3826-40
pubmed: 24623762
J Cell Biol. 2005 Oct 24;171(2):327-35
pubmed: 16230462
Nat Rev Neurol. 2010 Feb;6(2):99-107
pubmed: 20139999
Alzheimers Res Ther. 2014 Jul 03;6(4):37
pubmed: 25024750
J Neuropathol Exp Neurol. 1997 Sep;56(9):965-73
pubmed: 9291938
Neuron. 2019 Feb 6;101(3):399-411.e5
pubmed: 30595332
Brain Res Bull. 2016 Apr;122:1-11
pubmed: 26708939
PLoS Genet. 2019 May 31;15(5):e1008155
pubmed: 31150388
Mol Neurodegener. 2018 Oct 4;13(1):52
pubmed: 30286791
Med Phys. 1997 Jan;24(1):25-35
pubmed: 9029539
Neurology. 2014 Mar 25;82(12):1045-50
pubmed: 24598707
J Neurosci. 1997 Sep 15;17(18):7053-9
pubmed: 9278541
CPT Pharmacometrics Syst Pharmacol. 2012 Sep 26;1:e6
pubmed: 23835886
Neurobiol Aging. 2003 Dec;24(8):1063-70
pubmed: 14643377
Arch Neurol. 2008 Nov;65(11):1509-17
pubmed: 19001171
Expert Opin Drug Discov. 2012 Apr;7(4):281-97
pubmed: 22458501
Mol Neurodegener. 2019 Dec 26;14(1):50
pubmed: 31878951
Drug Metab Dispos. 2003 May;31(5):510-8
pubmed: 12695336
Behav Brain Res. 2008 Aug 22;191(2):246-55
pubmed: 18485495
Alzheimers Dement (N Y). 2020 Jun 14;6(1):e12038
pubmed: 32548237
J Neurosci. 2005 Jun 1;25(22):5446-54
pubmed: 15930395
Brain. 2007 Nov;130(Pt 11):2837-44
pubmed: 17928318
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
Neurobiol Aging. 2015 Dec;36(12):3152-3162
pubmed: 26422359
Nephron Clin Pract. 2010;116(3):c224-34
pubmed: 20606483
Cell Rep. 2020 Jul 14;32(2):107908
pubmed: 32668255
Hum Mol Genet. 1997 Oct;6(11):1951-9
pubmed: 9302276
Nature. 2011 Apr 7;472(7341):20
pubmed: 21475170
Neuroscience. 1999;91(3):819-30
pubmed: 10391465
N Engl J Med. 2013 Jan 10;368(2):117-27
pubmed: 23150934
J Intern Med. 2014 Mar;275(3):284-95
pubmed: 24605809
Neurosci Biobehav Rev. 2020 Sep;116:452-453
pubmed: 32681939
J Nucl Med. 2007 Apr;48(4):602-7
pubmed: 17401098
Proc Natl Acad Sci U S A. 2006 May 2;103(18):7130-5
pubmed: 16641106
J Biol Chem. 1999 Mar 5;274(10):6483-92
pubmed: 10037741
J Biol Chem. 2001 Jun 15;276(24):21562-70
pubmed: 11279122
J Neurosci. 2009 Aug 26;29(34):10741-9
pubmed: 19710325
Adv Drug Deliv Rev. 2001 Jun 11;48(2-3):265-300
pubmed: 11369086
Hum Mol Genet. 2006 Aug 1;15(15):2313-23
pubmed: 16785251
JAMA Neurol. 2015 Oct;72(10):1124-31
pubmed: 26302353
Acta Neuropathol. 2006 Jun;111(6):503-9
pubmed: 16718346
Alzheimers Res Ther. 2011 Sep 28;3(5):28
pubmed: 21943025
J Neurochem. 2003 Aug;86(3):582-90
pubmed: 12859672