Molecular role of cytochrome P4501A enzymes inoxidative stress.
Cytochrome P450 1A (CYP1A) enzymes
epoxyeicosatrienoic acid (EETs)
hydroxyeicosatetraenoic acid (HETEs)
oxidative stress
reaction uncoupling
reactive oxygen species (ROS)
Journal
Current opinion in toxicology
ISSN: 2468-2934
Titre abrégé: Curr Opin Toxicol
Pays: Netherlands
ID NLM: 101697847
Informations de publication
Date de publication:
Historique:
entrez:
7
12
2020
pubmed:
8
12
2020
medline:
8
12
2020
Statut:
ppublish
Résumé
Cytochrome P4501A (CYP1A) enzymes play important roles in xenobiotic and endobiotic metabolism. Due to uncoupling reactions during the enzymatic cycle, CYP1A enzymes can release reactive oxidative species (ROS) in the form of superoxide radical, hydrogen peroxide, hydroxyl radical etc. An imbalance between production of free radicals and the ability of antioxidants to detoxify the free radicals can lead to accumulation of ROS, which in turn can lead to oxidative stress. Oxidative stress can lead to inflammation and toxicity, which in turn can cause human diseases such as bronchopulmonary disease (BPD), ARDS, renal hypertension, etc. CYP1A enzymes, depending on the organ system, they either contribute or protect against oxidative injury. Thus, they have dual roles in regard to oxidative stress. This review presents an overview of the mechanistic relationship between CYP1A enzymes and oxidative stress in relation to various diseases in different organs (e.g., liver, lungs, heart, kidneys, and reproductive organs).
Identifiants
pubmed: 33283080
doi: 10.1016/j.cotox.2020.07.001
pmc: PMC7709944
mid: NIHMS1622806
doi:
Types de publication
Journal Article
Langues
eng
Pagination
77-84Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES009132
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019689
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087174
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES027725
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029382
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070921
Pays : United States
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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